The serine/threonine kinase CHK2 is a key component of the DNA damage response. In
human cells, following genotoxic stress, CHK2 is activated and phosphorylates> 20 proteins …

Interactions between the host and viruses during the course of their co-evolution have not
only shaped cellular function and the immune system, but also the counter measures …

Epstein-Barr virus (EBV) is a ubiquitous gammaherpesvirus which asymptomatically infects
the majority of the world population. Under immunocompromised conditions, EBV can …

To replicate their genomes in cells and generate new progeny, viruses typically require
factors provided by the cells that they have infected. Subversion of the cellular machinery …

Summary Epstein-Barr virus (EBV), an oncogenic herpesvirus that causes human
malignancies, infects and immortalizes primary human B cells in vitro into indefinitely …

Epstein–Barr virus (EBV) was first discovered in 1964, and was the first known human tumor
virus now shown to be associated with a vast number of human diseases. Numerous studies …

It is clear that a number of host-cell factors facilitate virus replication and, conversely, a
number of other factors possess inherent antiviral activity. Research, particularly over the …

RNA viruses are a genetically diverse group of pathogens that are responsible for some of
the most prevalent and lethal human diseases. Numerous viruses introduce DNA damage …

Epstein–Barr virus (EBV) has been implicated in the pathogenesis of human malignancies,
but its contribution to tumorigenesis is not well understood. EBV carriage is associated with …

As an inhibitor of cyclin-dependent kinases, p16INK4A is an important tumour suppressor
and inducer of cellular senescence that is often inactivated during the development of …