Alzheimer's disease (AD) was used to describe pre-senile dementia to differentiate it from
senile dementia, which develops in the adult age group of more than 65 years. AD is …

Although an immense knowledge has accumulated concerning regulation of cholesterol
homeostasis in the body, this does not include the brain, where details are just emerging …

Preventing or postponing the onset of Alzheimer's disease (AD) and delaying or slowing its
progression would lead to a consequent improvement of health status and quality of life in …

Animal models aim to replicate the symptoms, the lesions or the cause (s) of Alzheimer
disease. Numerous mouse transgenic lines have now succeeded in partially reproducing its …

High fat diets and sedentary lifestyles are becoming major concerns for Western countries.
They have led to a growing incidence of obesity, dyslipidemia, high blood pressure, and a …

Mutations in the amyloid precursor protein (APP) cause early-onset Alzheimer's disease
(AD), but the only genetic risk factor for late-onset AD is the ɛ4 allele of apolipoprotein E …

Diets rich in cholesterol and/or saturated fats have been shown to be detrimental to cognitive
performance. Therefore, we fed a cholesterol (2%) and saturated fat (hydrogenated coconut …

Lipid rafts are sphingolipid‐and cholesterol‐rich domains of the plasma membrane which
contain a variety of signalling and transport proteins. Different subtypes of lipid rafts can be …

Recent experimental and clinical retrospective studies support the view that reduction of
brain cholesterol protects against Alzheimer's disease (AD). However, genetic and …

Amyloid β-peptide (Aβ) accumulation in specific brain regions is a pathological hallmark of
Alzheimer's disease (AD). We have previously reported that a well-characterized acyl …