Adiponectin is the richest adipokine in human plasma, and it is mainly secreted from white
adipose tissue. Adiponectin circulates in blood as high-molecular, middle-molecular, and …

Oxidative stress and inflammation interact in the development of diabetic atherosclerosis.
Intracellular hyperglycemia promotes production of mitochondrial reactive oxygen species …

Rates of obesity and diabetes have increased significantly over the past decades and the
prevalence is expected to continue to rise further in the coming years. Many observations …

During the last 40 years, there has been a world-wide increase in both the prevalence of
obesity and an increase in the number of persons over the age of 60 due to a decline in …

Adipose tissue has traditionally been defined as connective tissue that stores excess
calories in the form of triacylglycerol. However, the physiologic functions attributed to …

Obesity-linked type 2 diabetes is one of the paramount causes of morbidity and mortality
worldwide, posing a major threat on human health, productivity, and quality of life. Despite …

Cross-talk between adipose tissue and central nervous system (CNS) underlies the
increased risk of obese people to develop brain diseases such as cognitive and mood …

Improving physical function and mobility in a continuously expanding elderly population
emerges as a high priority of medicine today. Muscle mass, strength/power, and maximal …

The discovery of adiponectin and subsequently the receptors it acts upon have lead to a
great surge forward in the understanding of the development of insulin resistance and …

Adiponectin is a fat-derived hormone whose reduction plays central roles in obesity-linked
diseases including insulin resistance/type 2 diabetes and atherosclerosis. The cloning of …