Plasmodium vivax vaccine: What is the best way to go?

GTS Veiga, MR Moriggi, JF Vettorazzi… - Frontiers in …, 2023 - frontiersin.org
Malaria is one of the most devastating human infectious diseases caused by Plasmodium
spp. parasites. A search for an effective and safe vaccine is the main challenge for its …

Plasmodium vivax: the potential obstacles it presents to malaria elimination and eradication

K Habtamu, B Petros, G Yan - Tropical Diseases, Travel Medicine and …, 2022 - Springer
Initiatives to eradicate malaria have a good impact on P. falciparum malaria worldwide. P.
vivax, however, still presents significant difficulties. This is due to its unique biological traits …

Genomic analysis of Plasmodium vivax describes patterns of connectivity and putative drivers of adaptation in Ethiopia

AM Kebede, E Sutanto, H Trimarsanto… - Scientific Reports, 2023 - nature.com
Ethiopia has the greatest burden of Plasmodium vivax in Africa, but little is known about the
epidemiological landscape of parasites across the country. We analysed the genomic …

Systems biology of malaria explored with nonhuman primates

MR Galinski - Malaria journal, 2022 - Springer
Abstract “The Primate Malarias” book has been a uniquely important resource for multiple
generations of scientists, since its debut in 1971, and remains pertinent to the present day …

Detection of Duffy blood group genotypes and submicroscopic Plasmodium infections using molecular diagnostic assays in febrile malaria patients

BR Abagero, R Rama, A Obeid, T Tolosa, B Lukas… - Malaria Journal, 2024 - Springer
Background Malaria remains a severe parasitic disease, posing a significant threat to public
health and hindering economic development in sub-Saharan Africa. Ethiopia, a malaria …

Potential hidden Plasmodium vivax malaria reservoirs from low parasitemia Duffy-negative Ethiopians: Molecular evidence

A Abebe, I Bouyssou, S Mabilotte… - PLoS neglected …, 2023 - journals.plos.org
Background The interaction between the Plasmodium vivax Duffy-binding protein and the
corresponding Duffy Antigen Receptor for Chemokines (DARC) is primarily responsible for …

Comparative transcriptomics reveal differential gene expression among Plasmodium vivax geographical isolates and implications on erythrocyte invasion …

D Kepple, CT Ford, J Williams, B Abagero… - PLOS Neglected …, 2024 - journals.plos.org
The documentation of Plasmodium vivax malaria across Africa especially in regions where
Duffy negatives are dominant suggests possibly alternative erythrocyte invasion …

Expression, Purification, and Characterization of Plasmodium vivax Lactate Dehydrogenase from Bacteria without Codon Optimization

YJ Kim, JS Shin, KW Lee, HJ Eom, BG Jo… - International Journal of …, 2023 - mdpi.com
Plasmodium vivax is the most widespread cause of malaria, especially in subtropical and
temperate regions such as Asia-Pacific and America. P. vivax lactate dehydrogenase …

Antibody response to a new member of the DBL family (EBP2) after a brief Plasmodium vivax exposure

BAS Lima, GM Fernandes, LM Torres… - PLOS Neglected …, 2022 - journals.plos.org
Plasmodium vivax blood-stage invasion into reticulocyte is critical for parasite development.
Thus, validation of novel parasite invasion ligands is essential for malaria vaccine …

Copy Number Variations of Plasmodium vivax DBP1, EBP/DBP2, and RBP2b in Ethiopians Who Are Duffy Positive and Duffy Negative

K Pestana, A Ford, R Rama, B Abagero… - The Journal of …, 2024 - academic.oup.com
Recent evidence challenges the belief that individuals who are Duffy-negative are resistant
to Plasmodium vivax due to lacking the Duffy antigen receptor for chemokines. Erythrocyte …