DNA damage by reactive species: Mechanisms, mutation and repair
NR Jena - Journal of biosciences, 2012 - Springer
DNA is continuously attacked by reactive species that can affect its structure and function
severely. Structural modifications to DNA mainly arise from modifications in its bases that …
severely. Structural modifications to DNA mainly arise from modifications in its bases that …
Formation of ring-opened and rearranged products of guanine: mechanisms and biological significance
DNA damage by endogenous and exogenous agents is a serious concern, as the damaged
products can affect genome integrity severely. Damage to DNA may arise from various …
products can affect genome integrity severely. Damage to DNA may arise from various …
A DFT study of reactions of methyldiazonium ion with DNA/RNA nucleosides: investigating effect of sugar moiety on methylation pattern of bases
K Bhattacharjee, PK Shukla - International Journal of Quantum …, 2014 - Wiley Online Library
Methyldiazonium ion () is an ultimate carcinogen that can methylate multiple sites in
DNA/RNA. In present contribution, density functional theory calculations using the B3LYP …
DNA/RNA. In present contribution, density functional theory calculations using the B3LYP …
Does 8-Nitroguanine Form 8-Oxoguanine? An Insight from Its Reaction with •OH Radical
K Bhattacharjee, PK Shukla - The Journal of Physical Chemistry B, 2018 - ACS Publications
8-Nitroguanine (8-nitroG) formed due to nitration of guanine base of DNA plays an important
role in mutagenesis and carcinogenesis. In the present contribution, state-of-the-art quantum …
role in mutagenesis and carcinogenesis. In the present contribution, state-of-the-art quantum …
Base pairing patterns of DNA base lesion spiroiminodihydantoin: A DFT study
The DNA base lesion spiroiminodihydantoin (Sp) is produced in biological systems
endogenously and can cause mutation and cancer. It is considered to be more mutagenic …
endogenously and can cause mutation and cancer. It is considered to be more mutagenic …
Mechanism of methylation of 8-oxoguanine due to its reaction with methyldiazonium ion
Anticancer drugs such as temozolomide (TMZ) and decarbazine (DTIC) and several
detrimental methylating agents methylate DNA via the formation of methyldiazonium ion () …
detrimental methylating agents methylate DNA via the formation of methyldiazonium ion () …
Cytotoxic and genotoxic effects of the trypanocidal drug diminazene aceturate
MD Baldissera, MR Sagrillo, TH Grando… - Comparative Clinical …, 2017 - Springer
Diminazene aceturate (DA) is an anti-parasitic drug that selectively targets adenine and
thymine bases of deoxyribonucleic acid (DNA) of trypanosomes; however, there are some …
thymine bases of deoxyribonucleic acid (DNA) of trypanosomes; however, there are some …
Formation of bifunctional cross-linked products due to reaction of NAMI-A with DNA bases–a DFT study
PK Shah, PK Shukla - Structural Chemistry, 2022 - Springer
It is reported that NAMI-A and other Ru-anticancer complexes preferably bind with the N7
site of guanine and can also form DNA inter-strand cross-links. Therefore, in order to …
site of guanine and can also form DNA inter-strand cross-links. Therefore, in order to …
Oxidative stress in cardiac remodeling post-ischemia/reperfusion: friend or foe?
Acute coronary artery disease remains the leading cause of death in the USA and most
westernized cultures. Notwithstanding the promising pharmacological and interventional …
westernized cultures. Notwithstanding the promising pharmacological and interventional …
Effect of N7-methylation on base pairing patterns of guanine: A DFT study
In this paper, we aim to determine whether the N7-methylation can influence the base
pairing properties of guanine by promoting the formation of guanine enol-tautomers. The …
pairing properties of guanine by promoting the formation of guanine enol-tautomers. The …