Pyrimidine: An elite heterocyclic leitmotif in drug discovery‐synthesis and biological activity
Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they
constitute an important class of natural and synthetic compounds exhibiting diverse useful …
constitute an important class of natural and synthetic compounds exhibiting diverse useful …
Importance of Hybrid Catalysts toward the Synthesis of 5H-Pyrano[2,3-d]pyrimidine-2-ones/2,4-diones (Thiones)
The pyranopyrimidine core is a key precursor for medicinal and pharmaceutical industries
due to its broader synthetic applications as well as its bioavailability. Among its four possible …
due to its broader synthetic applications as well as its bioavailability. Among its four possible …
Promising antidiabetic and antimicrobial agents based on fused pyrimidine derivatives: molecular modeling and biological evaluation with histopathological effect
Diabetes is the most common metabolic disorder in both developing and non-developing
countries, and a well-recognized global health problem. The WHO anticipates an increase in …
countries, and a well-recognized global health problem. The WHO anticipates an increase in …
Synthesis, biological evaluation and molecular docking study of 1, 2, 3-1H-triazoles having 4H-pyrano [2, 3-d] pyrimidine as potential Mycobacterium tuberculosis …
ND Thanh, NTT Ha, CT Le, HTK Van, VN Toan… - Bioorganic & medicinal …, 2019 - Elsevier
Abstract Some heterocycles, namely 2-amino-4H-pyran-3-carbonitriles, were synthesized in
a three-component reaction from substituted benzaldehydes, malononitrile, and ethyl …
a three-component reaction from substituted benzaldehydes, malononitrile, and ethyl …
A green synthesis of pyrimido [4, 5-b] quinolines and pyrido [2, 3-d] pyrimidines via a mechanochemical approach
A cost-effective and competent approach has been established for the synthesis of pyrimido
[4, 5-b] quinolines and pyrido [2, 3-d] pyrimidines via a multicomponent reaction of 1, 3 …
[4, 5-b] quinolines and pyrido [2, 3-d] pyrimidines via a multicomponent reaction of 1, 3 …
An insight on medicinal attributes of pyrimidine scaffold: An updated review
A Vyas, B Sahu, S Pathania, NK Nandi… - Journal of …, 2023 - Wiley Online Library
Pyrimidine itself or in different fused forms is an important chemical motif for every step of
cell life. Alongside, it exists as a key pharmacophoric part in thiamine, alloxan, orotic acid …
cell life. Alongside, it exists as a key pharmacophoric part in thiamine, alloxan, orotic acid …
One‐pot and two‐pot methods for chalcone derived pyrimidines synthesis and applications
Chalcone‐derived pyrimidine is a well‐known heterocyclic compound that is commonly
present in ribonucleic acid (RNA) and deoxyribonucleic acid (DNA) bio‐isosteres …
present in ribonucleic acid (RNA) and deoxyribonucleic acid (DNA) bio‐isosteres …
Green and highly efficient MCR strategy for the synthesis of pyrimidine analogs in water via C–C and C–N bond formation and docking studies
The current study deals with the synthesis of some novel pyrimidine derivatives by the
reaction of aromatic aldehydes, 2-aminobenzothiazole, and dimedone in the presence of …
reaction of aromatic aldehydes, 2-aminobenzothiazole, and dimedone in the presence of …
Microwave induced green synthesis: sustainable Technology for efficient development of bioactive pyrimidine scaffolds
Microwave radiation is used as a heating source during the synthesis of heterocyclic
compounds. The heating mechanisms involved in microwave-induced synthesis include …
compounds. The heating mechanisms involved in microwave-induced synthesis include …
Recent advances in the synthesis of bioactive glycohybrids via click-chemistry
Carbohydrates, traditionally known for their energy-providing role, have gained significant
attention in drug discovery due to their diverse bioactivities and stereodiversity. However …
attention in drug discovery due to their diverse bioactivities and stereodiversity. However …