The discovery of interleukin (IL)-17-producing CD4+ T (Th17) cells as a unique T-helper cell
lineage has revised our understanding of T-cell-mediated tissue injury. Recent data from …

Statins, a class of drugs that act as inhibitors of cholesterol biosynthesis and protein
isoprenylation, have been proposed as immunomodulatory agents due to their potent effects …

Abstract Background. Dysregulation of CD4+ T cell subsets participates in the pathogenesis
of IgA nephropathy (IgAN). FoxP3+ regulatory T cells (Treg) and Th17 cells are two novel …

Statins are pharmacological inhibitors of the activity of 3-hydroxy-3-methyl-glutaryl-CoA
reductase (HMGCR), an enzyme responsible for the synthesis of cholesterol. Some recent …

Statins beside their main effect on reducing the progression of cardiovascular disease
through pharmacological inhibition of the endogenous cholesterol synthesis, have …

Alport syndrome is a familial kidney disease caused by defects in the collagen type IV
network of the glomerular basement membrane. Lack of collagen-α3α4α5 (IV) changes the …

Inhibitors of HMG-CoA reductase (statins) are the major group of lipid-lowering drugs. Along
with hypocholesterolemic activity, statins exhibit anti-inflammatory and immunomodulatory …

Macrophages are heterogeneous and include classically activated M1 and alternatively
activated M2 macrophages, characterized by pro-and anti-inflammatory functions …

The HMG-CoA reductase inhibitors (statins) are used extensively in the treatment of
hyperlipidemia. They have also demonstrated a benefit in a variety of other disease …

Objective. The antifibrotic effect of simvastatin has been demonstrated in human lung
fibroblasts. This study aimed to measure the effects of simvastatin in the development of …