The advent of clustered regularly interspaced short palindromic repeat (CRISPR) genome
editing, coupled with advances in computing and imaging capabilities, has initiated a new …

Programmable gene-editing tools have transformed the life sciences and have shown
potential for the treatment of genetic disease. Among the CRISPR–Cas technologies that …

Understanding cellular responses to genetic perturbation is central to numerous biomedical
applications, from identifying genetic interactions involved in cancer to developing methods …

Large pretrained models have become foundation models leading to breakthroughs in
natural language processing and related fields. Developing foundation models for …

Despite the notable success of chimeric antigen receptor (CAR) T cell therapies in the
treatment of certain haematological malignancies, challenges remain in optimizing CAR …

The discovery of the CRISPR/Cas genome-editing system has revolutionized our
understanding of the plant genome. CRISPR/Cas has been used for over a decade to …

Multiple sclerosis (MS) involves the infiltration of autoreactive T cells into the CNS, yet we
lack a comprehensive understanding of the signaling pathways that regulate this process …

CRISPR interference (CRISPRi) enables programmable, reversible, and titratable
repression of gene expression (knockdown) in mammalian cells. Initial CRISPRi-mediated …

Summary Interferon-γ (IFN-γ) signaling mediates host responses to infection, inflammation
and anti-tumor immunity. Mutations in the IFN-γ signaling pathway cause immunological …

The ever-growing compendium of genetic variants associated with human pathologies
demands new methods to study genotype–phenotype relationships in complex tissues in a …