This review focuses on the role of oxidative processes in atherosclerosis and its resultant
cardiovascular events. There is now a consensus that atherosclerosis represents a state of …

Defining new approaches for the prevention and treatment of atherosclerosis is an important
priority. Recently, measurement of endothelial function in patients has emerged as a useful …

The current recommended dietary allowance (RDA) for vitamin C for adult nonsmoking men
and women is 60 mg/d, which is based on a mean requirement of 46 mg/d to prevent the …

The vascular endothelium is involved in the release of various vasodilators, including nitric
oxide (NO), prostacyclin and endothelium-derived hyperpolarizing factor, as well as …

1. Background: the concept of 'endothelial dysfunc- deficiency of either the substrate for the
enzyme NO tion' synthase or one of its critical co-factors. Alterations of endothelial cell …

The endothelium plays a key role in vascular homeostasis through the release of a variety of
autocrine and paracrine substances (1). In addition to vasodilation, a healthy endothelium is …

Endogenous oxidative damage to proteins, lipids, and DNA is thought to be an important
etiologic factor in aging and the development of chronic diseases such as cancer …

The vascular endothelium secretes factors that not only modulate blood vessel tone, but also
participate in the development and progression of atherosclerosis through their effects on …

The antioxidant properties of β-carotene, in addition to its proposed immunomodulatory
effects, have often been cited as the factors underlying its role in preventing disease …

The endothelium is essential for the maintenance of vascular homeostasis. Central to this
role is the production of endothelium-derived nitric oxide (EDNO), synthesized by the …