Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host
systemic inflammatory and immune response to infection. Over decades, advanced …

The homeostatic blood protease, activated protein C (APC), can function as (1) an
antithrombotic on the basis of inactivation of clotting factors Va and VIIIa;(2) a cytoprotective …

Endothelial cell protein C receptor (EPCR) was first identified and isolated as a cellular
receptor for protein C on endothelial cells. EPCR plays a crucial role in the protein C …

Activated protein C (APC) exerts endothelial cytoprotective actions that require protease-
activated receptor 1 (PAR1), whereas thrombin acting via PAR1 causes endothelial …

The protein C pathway provides multiple important functions to maintain a regulated balance
between hemostasis and host defense systems in response to vascular and inflammatory …

Protein C is a plasma serine protease zymogen whose active form, activated protein C
(APC), exerts potent anticoagulant activity. In addition to its antithrombotic role as a plasma …

Significance: Burns are debilitating, life threatening, and difficult to assess and manage.
Recent advances in assessment and management have occurred since a comprehensive …

Endothelial cells express several types of integral membrane protein receptors, which upon
interaction and activation by their specific ligands, initiate a signalling network that links …

Activated protein C (APC) cleaves protease-activated receptor 1 (PAR1) in vitro at R46 to
initiate beneficial cell signaling; however, thrombin and APC can cleave at R41. To elucidate …

Plasma protein C is a serine protease zymogen that is transformed into the active, trypsin-
like protease, activated protein C (APC), which can exert multiple activities. For its …