Reconstructing lineage relationships between cells within a tissue or organism is a long-
standing aim in biology. Traditionally, lineage tracing has been achieved through the …

Metastatic cancer is a major cause of death and remains largely incurable. A better
understanding of metastasis is therefore desperately needed to improve prognosis for late …

Molecular mechanisms underlying breast cancer lymph node metastasis remain unclear.
Using single-cell sequencing, we investigated the transcriptome profile of 96,796 single …

Patterns of genomic evolution between primary and metastatic breast cancer have not been
studied in large numbers, despite patients with metastatic breast cancer having dismal …

Cancer immunogenomics is an emerging field that bridges genomics and immunology. The
establishment of large-scale genomic collaborative efforts along with the development of …

Cellular heterogeneity within and across tumors has been a major obstacle in
understanding and treating cancer, and the complex heterogeneity is masked if bulk tumor …

Breast cancer (BC) is the main cause of cancer-related mortality among women globally.
Despite substantial advances in the identification and management of primary tumors …

Circulating tumor cells (CTCs), detached from the primary tumor or metastases and shed in
the patient's bloodstream, represent a relatively easily obtainable sample of the cancer …

Uveitis is a severe autoimmune disease, and a common cause of blindness; however, its
individual cellular dynamics and pathogenic mechanism remain poorly understood. Herein …

Cancer arises through the accumulation of somatic mutations over time. An understanding of
the sequence of events during this process should allow both earlier diagnosis and better …