The activation of a substrate by a chiral catalyst is now regarded as one of the most powerful
strategies that can be employed in the art of asymmetric synthesis. 1 The development of …

1.1. General Heterocyclic compounds, especially nitrogen heterocycles, are the most
important class of compounds in the pharmaceutical and agrochemical industries, with …

Multicomponent reactions (MCRs) receive increasing attention because they address both
diversity and complexity in organic synthesis. Thus, in principle diverse sets of relatively …

In general, DA reactions can be classified into two types of suprafacial [π4s+ π2s]
cycloadditions:(i) the normal and (ii) inverse-electron-demand DA reactions (Scheme 1) …

During the past four years, the research of new synthetic methodologies for the rapid
construction of enantiomerically pure substituted indole has had a fruitful and important …

The first catalytic asymmetric inverse‐electron‐demand (IED) oxa‐Diels–Alder reaction of
ortho‐quinone methides, generated in situ from ortho‐hydroxybenzyl alcohols, has been …

Enantioenriched indole derivatives are widely found in natural products, pharmaceuticals
and bioactive compounds. Therefore, developing efficient methods for the synthesis of …

Chiral phosphoric acids derived from axially chiral biaryls and related chiral Brønsted acids
have emerged as an attractive and widely applicable class of enantioselective …

The aza-Diels Alder reaction has become one of the most widely used synthetic tools for the
preparation of N-containing 6-membered heterocycles. Numerous important developments …

Inherently chiral calix [4] arenes are an excellent structural scaffold for enantioselective
synthesis, chiral recognition, sensing, and circularly polarized luminescence. However, their …