Recombinant mouse interleukin 10 (IL-10) was exceedingly potent at suppressing the ability
of mouse peritoneal macrophages (m phi) to release tumor necrosis factor alpha (TNF …

Abstract mdash;: Sepsis remains a serious clinical problem despite intense efforts to
improve survival. Experimental animal models of sepsis have responded dramatically to …

We have previously shown that two tumor necrosis factor (TNF) receptors (TNFR) exhibit
antagonistic functions during neurodegenerative processes in vivo with TNFR1 aggravating …

Using animal models or healthy volunteers, injection of lipopolysaccharide (LPS) or bacteria
causes activation of macrophages with excessive synthesis and secretion of …

Transforming growth factor (TGF)-beta and interleukin (IL)-10 inhibited lipopolysaccharide
(LPS)-induced macrophage production of the inflammatory cytokines tumor necrosis factor …

We tested the hypothesis that, during sepsis, the balance of pro-and anti-inflammatory
cytokines is related to severity and survival. Cecal ligation and puncture (CLP) with a large …

Cytokines have been studied intensively to delineate their role in the altered
pathophysiology observed in septic shock. We studied the role of TNF in the lethality of two …

We examined the relationship of pulmonary infection and inflammation in cystic fibrosis (CF)
by performing 31 bronchoalveolar lavages (BAL) in 14 young children with minimal lung …

We investigated inflammatory and physiologic parameters in sepsis models of increasing
lethality induced by cecal ligation and puncture (CLP). Mice received imipenem for antibiotic …

The hydroxyl radical (OH.) scavenger dimethyl sulfoxide (DMSO) was found to dose-
dependently inhibit interleukin 8 (IL-8) production in LPS-stimulated human whole blood. At …