Recent advances in our understanding of RNA biology have uncovered crucial roles for
RNA in multiple disease states, ranging from viral and bacterial infections to cancer and …

RNA viruses carry out selective packaging of their genomes in a variety of ways, many
involving a genomic packaging signal. The first coronavirus packaging signal was …

Background Antiretroviral therapy (ART) halts HIV-1 replication, decreasing viremia to below
the detection limit of clinical assays. However, some individuals experience persistent …

During the last forty years we have witnessed impressive advances in the field of antiviral
drug discovery culminating with the introduction of therapies able to stop human …

Genome-wide measurements of RNA structure can be obtained using reagents that react
with unpaired bases, leading to adducts that can be identified by mutational profiling on next …

Viral capsids are often regarded as inert structural units, but in actuality they display
fascinating dynamics during different stages of their life cycle. With the advent of single …

The extreme 5′-end of the enterovirus RNA genome contains a conserved cloverleaf-like
domain that recruits 3CD and PCBP proteins required for initiating genome replication …

In light of the Covid-19 outbreak, this review brings together historical and current literature
efforts towards the development of antiviral metallodrugs. Classical compounds such as …

It is well-established that dynamics are central to protein function; their importance is
implicitly acknowledged in the principles of the Monod, Wyman and Changeux model of …

RNA is a unique bio-macromolecule that can both record genetic information and perform
biological functions in a variety of molecular processes, including transcription, splicing …