Neural control of breathing and CO2 homeostasis
PG Guyenet, DA Bayliss - Neuron, 2015 - cell.com
Recent advances have clarified how the brain detects CO 2 to regulate breathing (central
respiratory chemoreception). These mechanisms are reviewed and their significance is …
respiratory chemoreception). These mechanisms are reviewed and their significance is …
[HTML][HTML] Regulation of breathing and autonomic outflows by chemoreceptors
PG Guyenet - Comprehensive Physiology, 2014 - ncbi.nlm.nih.gov
Lung ventilation fluctuates widely with behavior but arterial PCO 2 remains stable. Under
normal conditions, the chemoreflexes contribute to PaCO 2 stability by producing small …
normal conditions, the chemoreflexes contribute to PaCO 2 stability by producing small …
The retrotrapezoid nucleus: central chemoreceptor and regulator of breathing automaticity
PG Guyenet, RL Stornetta, GMPR Souza… - Trends in …, 2019 - cell.com
The ventral surface of the rostral medulla oblongata has been suspected since the 1960s to
harbor central respiratory chemoreceptors [ie, acid-activated neurons that regulate breathing …
harbor central respiratory chemoreceptors [ie, acid-activated neurons that regulate breathing …
Active expiration induced by excitation of ventral medulla in adult anesthetized rats
Data from perinatal and juvenile rodents support our hypothesis that the preBötzinger
complex generates inspiratory rhythm and the retrotrapezoid nucleus–parafacial respiratory …
complex generates inspiratory rhythm and the retrotrapezoid nucleus–parafacial respiratory …
The chemical neuroanatomy of breathing
GF Alheid, DR McCrimmon - Respiratory physiology & neurobiology, 2008 - Elsevier
The chemical neuroanatomy of breathing must ultimately encompass all the various
neuronal elements physiologically identified in brainstem respiratory circuits and their …
neuronal elements physiologically identified in brainstem respiratory circuits and their …
Proton detection and breathing regulation by the retrotrapezoid nucleus
PG Guyenet, DA Bayliss, RL Stornetta… - The Journal of …, 2016 - Wiley Online Library
We discuss recent evidence which suggests that the principal central respiratory
chemoreceptors are located within the retrotrapezoid nucleus (RTN) and that RTN neurons …
chemoreceptors are located within the retrotrapezoid nucleus (RTN) and that RTN neurons …
Acid sensitivity and ultrastructure of the retrotrapezoid nucleus in Phox2b‐EGFP transgenic mice
RM Lazarenko, TA Milner, SD Depuy… - Journal of …, 2009 - Wiley Online Library
The retrotrapezoid nucleus (RTN) contains noncholinergic noncatecholaminergic
glutamatergic neurons that express the transcription factor Phox2b (chemically coded or “cc” …
glutamatergic neurons that express the transcription factor Phox2b (chemically coded or “cc” …
Selective lesion of retrotrapezoid Phox2b‐expressing neurons raises the apnoeic threshold in rats
AC Takakura, TS Moreira, RL Stornetta… - The Journal of …, 2008 - Wiley Online Library
Injection of the neurotoxin saporin–substance P (SSP‐SAP) into the retrotrapezoid nucleus
(RTN) attenuates the central chemoreflex in rats. Here we ask whether these deficits are …
(RTN) attenuates the central chemoreflex in rats. Here we ask whether these deficits are …
Caudal nuclei of the rat nucleus of the solitary tract differentially innervate respiratory compartments within the ventrolateral medulla
GF Alheid, W Jiao, DR McCrimmon - Neuroscience, 2011 - Elsevier
A substantial array of respiratory, cardiovascular, visceral and somatic afferents are relayed
via the nucleus of the solitary tract (NTS) to the brainstem (and forebrain). Despite some …
via the nucleus of the solitary tract (NTS) to the brainstem (and forebrain). Despite some …
Retrotrapezoid nucleus, respiratory chemosensitivity and breathing automaticity
PG Guyenet, DA Bayliss, RL Stornetta… - Respiratory physiology …, 2009 - Elsevier
Breathing automaticity and CO2 regulation are inseparable neural processes. The
retrotrapezoid nucleus (RTN), a group of glutamatergic neurons that express the …
retrotrapezoid nucleus (RTN), a group of glutamatergic neurons that express the …