Recent advances in single molecule experiments have raised many challenges. These
challenges can be met by a proper understanding of the inter-and intra-molecular …

Despite the recent advances in the prediction of protein structures by deep neutral networks,
the elucidation of protein-folding mechanisms remains challenging. A promising theory for …

Protein energy landscapes are highly complex, yet the vast majority of states within them
tend to be invisible to experimentalists. Here, using site-directed mutagenesis and exploiting …

The mechanical unfolding of an engineered protein composed of eight domains of Ig27 is
investigated by using atomic force microscopy. Exploiting a fluctuation relation, the …

We investigate the mechanical unfolding of the tenth type III domain from fibronectin (FnIII
10) both at constant force and at constant pulling velocity, by all-atom Monte Carlo …

Mechanical unfolding and refolding of ubiquitin are studied by Monte Carlo simulations of a
Gō model with binary variables. The exponential dependence of the time constants on the …

Protecting osmolytes are widespread small organic molecules able to stabilize the folded
state of most proteins against various denaturing stresses in vivo. The osmophobic model …

We show via single-molecule mechanical unfolding experiments that the osmolyte glycerol
stabilizes the native state of the human cardiac I27 titin module against unfolding without …

In a cellular environment, confinement and macromolecular crowding play an important role
in thermal stability and folding kinetics of a protein. We have resorted to a generalized …

We apply the Wako-Saito-Muñoz-Eaton model to the study of myotrophin, a small ankyrin
repeat protein, whose folding equilibrium and kinetics have been recently characterized …