Mismatch repair
The concept of mismatch repair (MMR) was formulated independently in 1964 to explain the
removal of brominated nucleotides from DNA as well as gene conversion during genetic …
removal of brominated nucleotides from DNA as well as gene conversion during genetic …
Postreplicative mismatch repair
J Jiricny - Cold Spring Harbor perspectives in biology, 2013 - cshperspectives.cshlp.org
The mismatch repair (MMR) system detects non-Watson–Crick base pairs and strand
misalignments arising during DNA replication and mediates their removal by catalyzing …
misalignments arising during DNA replication and mediates their removal by catalyzing …
DNA methyltransferases and epigenetic regulation in bacteria
S Adhikari, PD Curtis - FEMS microbiology reviews, 2016 - academic.oup.com
Epigenetics is a change in gene expression that is heritable without a change in DNA
sequence itself. This phenomenon is well studied in eukaryotes, particularly in humans for …
sequence itself. This phenomenon is well studied in eukaryotes, particularly in humans for …
Bacterial DNA excision repair pathways
KJ Wozniak, LA Simmons - Nature Reviews Microbiology, 2022 - nature.com
Bacteria are continuously exposed to numerous endogenous and exogenous DNA-
damaging agents. To maintain genome integrity and ensure cell survival, bacteria have …
damaging agents. To maintain genome integrity and ensure cell survival, bacteria have …
Mismatch repair during homologous and homeologous recombination
Homologous recombination (HR) and mismatch repair (MMR) are inextricably linked. HR
pairs homologous chromosomes before meiosis I and is ultimately responsible for …
pairs homologous chromosomes before meiosis I and is ultimately responsible for …
Temporally and biochemically distinct activities of Exo1 during meiosis: double-strand break resection and resolution of double Holliday junctions
K Zakharyevich, Y Ma, S Tang, PYH Hwang, S Boiteux… - Molecular cell, 2010 - cell.com
The Rad2/XPG family nuclease, Exo1, functions in a variety of DNA repair pathways. During
meiosis, Exo1 promotes crossover recombination and thereby facilitates chromosome …
meiosis, Exo1 promotes crossover recombination and thereby facilitates chromosome …
PCNA activates the MutLγ endonuclease to promote meiotic crossing over
DS Kulkarni, SN Owens, M Honda, M Ito, Y Yang… - Nature, 2020 - nature.com
During meiosis, crossover recombination connects homologous chromosomes to direct their
accurate segregation. Defective crossing over causes infertility, miscarriage and congenital …
accurate segregation. Defective crossing over causes infertility, miscarriage and congenital …
DNA repair and genome maintenance in Bacillus subtilis
JS Lenhart, JW Schroeder, BW Walsh… - … and molecular biology …, 2012 - Am Soc Microbiol
From microbes to multicellular eukaryotic organisms, all cells contain pathways responsible
for genome maintenance. DNA replication allows for the faithful duplication of the genome …
for genome maintenance. DNA replication allows for the faithful duplication of the genome …
Integrating chemical mutagenesis and whole-genome sequencing as a platform for forward and reverse genetic analysis of Chlamydia
Gene inactivation by transposon insertion or allelic exchange is a powerful approach to
probe gene function. Unfortunately, many microbes, including Chlamydia, are not amenable …
probe gene function. Unfortunately, many microbes, including Chlamydia, are not amenable …
Mlh1-Mlh3, a meiotic crossover and DNA mismatch repair factor, is a Msh2-Msh3-stimulated endonuclease
Crossing over between homologous chromosomes is initiated in meiotic prophase in most
sexually reproducing organisms by the appearance of programmed double strand breaks …
sexually reproducing organisms by the appearance of programmed double strand breaks …