Manufacturing the multiscale vascular hierarchy: progress toward solving the grand challenge of tissue engineering

EA Margolis, NE Friend, MW Rolle, E Alsberg… - Trends in …, 2023 - cell.com
In human vascular anatomy, blood flows from the heart to organs and tissues through a
hierarchical vascular tree, comprising large arteries that branch into arterioles and further …

[HTML][HTML] 3D engineered tissue models for studying human-specific infectious viral diseases

KS Hwang, EU Seo, N Choi, J Kim, HN Kim - Bioactive Materials, 2023 - Elsevier
Viral infections cause damage to various organ systems by inducing organ-specific
symptoms or systemic multi-organ damage. Depending on the infection route and virus type …

Bio-inspired microvascular patches with MSC encapsulation for wound healing

R Liu, B Kong, J Gan, Y Zhao, L Sun - Chemical Engineering Journal, 2023 - Elsevier
Mesenchymal stem cells (MSCs) have been studied extensively for promoting wound
healing, while their practical applications remain challenging due to the difficulty of …

Bioengineering of high cell density tissues with hierarchical vascular networks for ex vivo whole organs

P Wu, H Asada, M Hakamada… - Advanced Materials, 2023 - Wiley Online Library
The development of tissue‐like structures such as cell sheets, spheroids, and organoids has
contributed to progress in regenerative medicine. Simultaneous achievement of scale up …

Engineering pre-vascularized 3D tissue and rapid vascular integration with host blood vessels via co-cultured spheroids-laden hydrogel

H Kwon, S Lee, H Byun, SJ Huh, E Lee, E Kim… - …, 2024 - iopscience.iop.org
Recent advances in regenerative medicine and tissue engineering have enabled the
biofabrication of three-dimensional (3D) tissue analogues with the potential for use in …

3D printed microfluidics for cell biological applications

L Zhao, X Wang - TrAC Trends in Analytical Chemistry, 2023 - Elsevier
Over past decades, microfluidics has been proven to be a valuable tool for cell biological
research due to several merits, including size compatibility with cells, controllability with …

Engineered vasculature for cancer research and regenerative medicine

HT Nguyen, A Peirsman, Z Tirpakova, K Mandal… - Micromachines, 2023 - mdpi.com
Engineered human tissues created by three-dimensional cell culture of human cells in a
hydrogel are becoming emerging model systems for cancer drug discovery and …

A Transwell-Based Vascularized Model to Investigate the Effect of Interstitial Flow on Vasculogenesis

P Deng, M Zhao, X Zhang, J Qin - Bioengineering, 2022 - mdpi.com
Interstitial flow plays a significant role in vascular system development, mainly including
angiogenesis and vasculogenesis. However, compared to angiogenesis, the effect of …

Passive-Flow-Based MPS: Emerging Physiological Flow-Mimetic Platforms for Studying Effects of Flow on Single Tissues and Inter-tissue Interactions

G Jin, D Kim, S Mun, S Bang - BioChip Journal, 2024 - Springer
Flow at various scales, such as perfusion flow and interstitial flow, is a critical component of
the physiology of living systems. Microphysiological system (MPS), which is designed to …

Moving lab-grown tissues into the clinic: organ-on-a-chip and bioengineered skin systems

CA Reed-McBain, JD Patel… - Frontiers in Lab on a …, 2024 - frontiersin.org
For patients with end stage organ failure, organ transplant is frequently the only curative
option available. However, organs available for transplant are in critically short supply …