Pathophysiological changes in the spinal cord white and grey matter resulting from injury
can be observed with MRI techniques. These techniques provide sensitive markers of …

The fiber g-ratio is the ratio of the inner to the outer diameter of the myelin sheath of a
myelinated axon. It has a limited dynamic range in healthy white matter, as it is optimized for …

We present distinct patterns of neurite distribution in the human cerebral cortex using
diffusion magnetic resonance imaging (MRI). We analyzed both high-resolution structural …

Healthy cognitive ageing is a societal and public health priority. Cerebrovascular risk factors
increase the likelihood of dementia in older people but their impact on cognitive ageing in …

Purpose Neurite orientation dispersion and density imaging (NODDI) provides measures of
neurite density and dispersion through computation of the neurite density index (NDI) and …

Advanced biophysical models like neurite orientation dispersion and density imaging
(NODDI) have been developed to estimate the microstructural complexity of voxels enriched …

Recent years have seen a growing interest in relating MRI measurements to the structural-
biophysical properties of white matter fibers. The fiber g-ratio, defined as the ratio between …

Background The g-ratio, quantifying the comparative thickness of the myelin sheath
encasing an axon, is a geometrical invariant that has high functional relevance because of …

Diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging
(NODDI) are widely used models to infer microstructural features in the brain from diffusion …

Abstract Background People with Parkinson's disease (PD) can develop multidomain
cognitive impairments; however, it is unclear whether different pathologies underlie domain …