Although rare, the prevalence of inherited platelet function disorders (IPFD) is probably
underestimated due to under‐diagnosis 1. IPFD are heterogeneous in severity, mechanisms …

Ensuring quality has become a daily requirement in laboratories. In haemostasis, even more
than in other disciplines of biology, quality is determined by a pre-analytical step that …

The management of perioperative bleeding involves multiple assessments and strategies to
ensure appropriate patient care. Initially, it is important to identify those patients with an …

Inherited bleeding, thrombotic, and platelet disorders (BPDs) are diseases that affect∼ 300
individuals per million births. With the exception of hemophilia and von Willebrand disease …

Platelets have been shown to be associated with pathophysiological processes beyond
thrombosis, demonstrating critical additional roles in homeostatic processes, such as …

Variations in platelet number, volume, and function are largely genetically controlled, and
many loci associated with platelet traits have been identified by genome-wide association …

The association between chronic kidney disease (CKD) and renal cell carcinoma (RCC) is
bidirectional and multifactorial. Risk factors such as hypertension, diabetes mellitus, obesity …

Excessive bleeding at surgery is a feared complication in patients with inherited platelet
disorders. However, very few studies have evaluated the frequency of surgical bleeding in …

Flow cytometry is increasingly used in the study of platelets in inherited and acquired
disorders of platelet number and function. However, wide variation exists in specific …

Platelet dense-granules are small organelles specific to the platelet lineage that contain
small molecules (calcium, adenyl nucleotides, serotonin) and are essential for the activation …