MHC class II molecules are pivotal for the adaptive immune system, because they guide the
development and activation of CD4+ T helper cells. Fulfilling these functions requires that …

The bare lymphocyte syndrome (BLS) is a hereditary immunodeficiency resulting from the
absence of major istocompatibility complex class II (MHCII) expression. Considering the …

Hereditary major histocompatibility complex (MHC) class II deficiency (or bare lymphocyte
syndrome) is a form of severe primary immunodeficiency with a total lack of MHC class II …

The lymphocyte activation gene 3 (LAG-3), expressed in human activated T and natural
killer (NK) cells, is closely related to CD4 at the gene and protein levels. We report here the …

Human Vγ2Vδ2+ T cells recognize mycobacterial non-peptide antigens, such as isopentenyl
pyrophosphate, and their synthetic analogs, such as monoethyl phosphate, through a TCR …

▪ Abstract Precise regulation of major histocompatibility complex class II (MHC-II) gene
expression plays a crucial role in the control of the immune response. A major breakthrough …

We describe functional simplified T cell and Fc receptor chimeras that are capable of
directing CD8+ cytotoxic T lymphocytes (CTLs) to specifically recognize and lyse cells …

By virtue of its control over major histocompatibility complex class II (MHC-II) gene
expression, CIITA represents a key molecule in the regulation of adaptive immune …

Around the turn of the century, it was found that tumors of a particular mouse would grow
only in mice of the same inbred strain, The ability to transplant both neoplastic and normal …

Construction of an optimal vaccine against tumors relies on the availability of appropriate
tumor-specific antigens capable to stimulate CD4+ T helper cells (TH) and CD8+ cytolytic T …