This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

Life's origin entails enclosing a compartment to hoard material, energy, and information. The
envelope necessarily comprises amphipaths, such as prebiotic fatty acids, to partition the …

The transduction of transmembrane electric fields into protein motion has an essential role in
the generation and propagation of cellular signals. Voltage-sensing domains (VSDs) carry …

Voltage-gated potassium channels play a fundamental role in the generation and
propagation of the action potential. The discovery of these channels began with predictions …

Perception of heat or cold in higher organisms is mediated by specialized ion channels
whose gating is exquisitely sensitive to temperature. The physicochemical underpinnings of …

The determination of membrane protein (MP) structures has always trailed that of soluble
proteins due to difficulties in their overexpression, reconstitution into membrane mimetics …

Membrane proteins possess a variety of functions essential to the survival of organisms.
However, due to their inherent hydrophobic nature, it is extremely difficult to probe the …

The voltage-gated proton channel Hv1 plays a critical role in the fast proton translocation
that underlies a wide range of physiological functions, including the phagocytic respiratory …

Site‐directed spin labeling (SDSL) in combination with electron paramagnetic resonance
(EPR) spectroscopy is a rapidly expanding powerful biophysical technique to study the …

The gating pore current, also called omega current, consists of a cation leak through the
typically nonconductive voltage-sensor domain (VSD) of voltage-gated ion channels …