The combination of synthetic and systems biology is a powerful framework to study
fundamental questions in biology and produce chemicals of immediate practical application …

Lignocellulose waste was served as promising raw material for bioethanol production.
Bioethanol was considered to be a potential alternative energy to take the place of fossil …

Background Heterologous expression systems based on promoters inducible with isopropyl-
β-D-1-thiogalactopyranoside (IPTG), eg, Escherichia coli BL21 (DE3) and cognate LacI Q/P …

Engineering metabolic biosynthetic pathways has enabled the microbial production of many
useful chemicals. However, pathway productivities and yields are often limited by metabolic …

Covering up to end 2015 Microbial fermentation provides an attractive alternative to
chemical synthesis for the production of structurally complex natural products. In most cases …

Mixed-acid fermentation end products have numerous applications in biotechnology. This is
probably the main driving force for the development of multiple strains that are supposed to …

The molecular mechanisms of ethanol toxicity and tolerance in bacteria, although important
for biotechnology and bioenergy applications, remain incompletely understood. Genetic …

Highlights•The rationale and underlying principles of multivariate modular metabolic
engineering (MMME) are given.•Several examples highlighting MMME's pathway …

Background Volatile carboxylic acids, alcohols, and esters are natural fermentative products,
typically derived from anaerobic digestion. These metabolites have important functional …

The microbial conversion of sugars to fuels is a promising technology, but the byproducts of
biomass pretreatment processes and the fuels themselves are often toxic at industrially …