Cancer metastasis and therapy resistance are the major unsolved clinical challenges, and
account for nearly all cancer-related deaths. Both metastasis and therapy resistance are …

Cellular differentiation is one of the hallmarks of complex multicellularity, allowing individual
organisms to capitalize on among-cell functional diversity. The evolution of multicellularity is …

Basal-like breast cancer is the most aggressive breast cancer subtype with the worst
prognosis. Despite its high recurrence rate, chemotherapy is the only treatment for basal-like …

Methods based around statistics and linear algebra have been increasingly used in attempts
to address emerging questions in microarray literature. Microarray technology is a long-used …

Dynamic interconversions between transitional epithelial and mesenchymal states underpin
the epithelial mesenchymal plasticity (EMP) seen in some carcinoma cell systems. We have …

Epithelial-to-mesenchymal transition (EMT) is a fundamental cellular process and plays an
essential role in development, tissue regeneration, and cancer metastasis. Interestingly …

Boolean networks (BNs) have been extensively used to model gene regulatory networks
(GRNs). The dynamics of BNs depend on the network architecture and regulatory logic rules …

Phenotypic plasticity of cancer cells can lead to complex cell state dynamics during tumor
progression and acquired resistance. Highly plastic stem-like states may be inherently drug …

Many clinical trials for cancer precision medicine have yielded unsatisfactory results due to
challenges such as drug resistance and low efficacy. Drug resistance is often caused by the …

Hematopoietic stem cells (HSCs) provide all types of blood cells during the entire life of the
organism. HSCs are mainly quiescent and can eventually enter the cell cycle to differentiate …