IgG from Adult Atopic Dermatitis (AD) Patients Induces Nonatopic Neonatal Thymic Gamma–Delta T Cells (γδT) to Acquire IL-22/IL-17 Secretion Profile with Skin …

BO Fagundes, TR de Sousa, A Nascimento… - International Journal of …, 2022 - mdpi.com
γδT cells mature in the human thymus, and mainly produce IL-17A or IFN-γ, but can also
produce IL-22 and modulate a variety of immune responses. Here, we aimed to evaluate …

IgG from adult atopic dermatitis (AD) patients induces thymic IL-22 production and CLA expression on CD4+ T cells: Possible epigenetic implications mediated by …

TR de Sousa, BO Fagundes, A Nascimento… - International Journal of …, 2022 - mdpi.com
Atopic dermatitis (AD) is a common relapsing inflammatory skin disorder characterized by
immune-mediated inflammation and epidermal barrier dysfunction. The pathogenesis of AD …

[HTML][HTML] Immune modulation and possible pathological implications mediated by naturally produced immunoglobulin G idiotypes: from historical to recent experimental …

L Santander, NR Machado, BO Fagundes… - Clinical and …, 2024 - ncbi.nlm.nih.gov
Since the 1950s decade, it has been suggested that a naturally produced or induced
repertoire of immunoglobulin G (IgG) idiotypes may exert some immunoregulatory functions …

Differential modulation of IL-4, IL-10, IL-17, and IFN-γ production mediated by IgG from Human T-lymphotropic virus-1 (HTLV-1) infected patients on healthy peripheral …

NR Machado, BO Fagundes, LA Fernandes… - Frontiers in …, 2023 - frontiersin.org
Human T-lymphotropic virus 1 (HTLV-1) infected individuals remain as asymptomatic
carriers (ACs) or can develop the chronic neurological disorder HTLV-1-associated …

IgG from Dermatophagoides pteronyssinus (Der p)-atopic individuals modulates non-atopic thymic B cell phenotype (alfa-4/beta-7) and cytokine production (IFN-γ, IL …

DT de-Apoena Reche, NR Machado, BO Fagundes… - Scientific Reports, 2024 - nature.com
Studies about thymic B cells are scarce in the literature, but it was suggested that they can
exert modulatory and regulatory functions on the immune system. Thymic B cells can play …

Do different IgG repertoires play a role in B‐and T‐cell functional modulation during ontogeny? The “hooks without bait” theory

JR Victor - Immunology and Cell Biology, 2020 - Wiley Online Library
The mechanisms by which immunoglobulin (Ig) G can modulate immunity have been
investigated over the past few decades. In the past three years, some studies have …

IgG from patients with mild or severe COVID‑19 reduces the frequency and modulates the function of peripheral mucosal-associated invariant T cells in PBMCs from …

NR Machado, BO Fagundes… - Biomedical …, 2023 - spandidos-publications.com
Lower levels of peripheral mucosal‑associated invariant T (MAIT) cells have been observed
in the peripheral blood of patients with severe coronavirus disease 2019 (COVID‑19) …

Natural self-ligand gamma delta T cell receptors (γδTCRs) insight: the potential of induced IgG

TR de Sousa, JR Victor - Vaccines, 2020 - mdpi.com
A γδ T cell acquires functional properties in response to the gamma delta T cell receptor
γδTCR signal strength during its development in the thymus. The elucidation of the potential …

The potential of IgG to induce murine and human thymic maturation of IL-10+ B Cells (B10) revealed in a pilot study

AHS Inoue, AAL Lira, MG De-Oliveira, TR de Sousa… - Cells, 2020 - mdpi.com
Regulatory B (B10) cells can control several inflammatory diseases, including allergies;
however, the origin of peripheral B10 cells is not fully understood, and the involvement of …

Preconceptional immunization with an allergen inhibits offspring thymic Th17 cells maturation without influence on Th1 and Th2 cells

MG de Oliveira, FR Sgnotto, TR de Sousa… - European Cytokine …, 2020 - Springer
The mechanisms through which maternal immunization can modulate offspring thymic
maturation of lymphocytes are not fully understood. Here, we aimed to evaluate whether …