The importance of comorbidities in ischemic stroke: Impact of hypertension on the cerebral circulation
MJ Cipolla, DS Liebeskind… - Journal of Cerebral Blood …, 2018 - journals.sagepub.com
Comorbidities are a hallmark of stroke that both increase the incidence of stroke and worsen
outcome. Hypertension is prevalent in the stroke population and the most important …
outcome. Hypertension is prevalent in the stroke population and the most important …
Physiology of local renin-angiotensin systems
Since the first identification of renin by Tigerstedt and Bergmann in 1898, the renin-
angiotensin system (RAS) has been extensively studied. The current view of the system is …
angiotensin system (RAS) has been extensively studied. The current view of the system is …
[HTML][HTML] Endothelial nitric oxide synthase (eNOS) and the cardiovascular system: in physiology and in disease states
N Tran, T Garcia, M Aniqa, S Ali, A Ally… - American journal of …, 2022 - ncbi.nlm.nih.gov
Endothelial nitric oxide synthase (eNOS) plays a critical role in regulating and maintaining a
healthy cardiovascular system. The importance of eNOS can be emphasized from the …
healthy cardiovascular system. The importance of eNOS can be emphasized from the …
Specific role of tight junction proteins claudin-5, occludin, and ZO-1 of the blood–brain barrier in a focal cerebral ischemic insult
H Jiao, Z Wang, Y Liu, P Wang, Y Xue - Journal of Molecular Neuroscience, 2011 - Springer
Blood–brain barrier (BBB) leakage plays a key role in cerebral ischemia–reperfusion injury.
It is quite necessary to further explore the characteristic and mechanism of BBB leakage …
It is quite necessary to further explore the characteristic and mechanism of BBB leakage …
[HTML][HTML] Hypertension and cerebrovascular dysfunction
C Iadecola, RL Davisson - Cell metabolism, 2008 - cell.com
Essential hypertension has devastating effects on the brain, being the major cause of stroke
and a leading cause of dementia. Hypertension alters the structure of cerebral blood vessels …
and a leading cause of dementia. Hypertension alters the structure of cerebral blood vessels …
Regional leptomeningeal score on CT angiography predicts clinical and imaging outcomes in patients with acute anterior circulation occlusions
BACKGROUND AND PURPOSE: The regional leptomeningeal score is a strong and
reliable imaging predictor of good clinical outcomes in acute anterior circulation ischemic …
reliable imaging predictor of good clinical outcomes in acute anterior circulation ischemic …
Neuroprotective effects of angiotensin receptor blockers
S Villapol, JM Saavedra - American journal of hypertension, 2015 - academic.oup.com
Angiotensin II receptor blockers (ARBs, collectively called sartans) are widely used
compounds therapeutically effective in cardiovascular disorders, renal disease, the …
compounds therapeutically effective in cardiovascular disorders, renal disease, the …
Prophylactic treatment of migraine with an angiotensin II ReceptorBlocker: a randomized controlled trial
E Tronvik, LJ Stovner, G Helde, T Sand, G Bovim - Jama, 2003 - jamanetwork.com
Context There is a paucity of effective, well-tolerated drugs available for migraine
prophylaxis. Objective To determine whether treatment with the angiotensin II receptor …
prophylaxis. Objective To determine whether treatment with the angiotensin II receptor …
Angiotensin II AT1 receptor blockers as treatments for inflammatory brain disorders
JM Saavedra - Clinical science, 2012 - portlandpress.com
The effects of brain AngII (angiotensin II) depend on AT1 receptor (AngII type 1 receptor)
stimulation and include regulation of cerebrovascular flow, autonomic and hormonal …
stimulation and include regulation of cerebrovascular flow, autonomic and hormonal …
Blockade of brain angiotensin II AT1 receptors ameliorates stress, anxiety, brain inflammation and ischemia: therapeutic implications
JM Saavedra, E Sánchez-Lemus, J Benicky - Psychoneuroendocrinology, 2011 - Elsevier
Poor adaptation to stress, alterations in cerebrovascular function and excessive brain
inflammation play critical roles in the pathophysiology of many psychiatric and neurological …
inflammation play critical roles in the pathophysiology of many psychiatric and neurological …