Advances in molecular classification and precision oncology in hepatocellular carcinoma
S Rebouissou, JC Nault - Journal of hepatology, 2020 - Elsevier
Hepatocellular carcinoma (HCC) arises from hepatocytes through the sequential
accumulation of multiple genomic and epigenomic alterations resulting from Darwinian …
accumulation of multiple genomic and epigenomic alterations resulting from Darwinian …
Function of the c-Met receptor tyrosine kinase in carcinogenesis and associated therapeutic opportunities
Abstract c-Met is a receptor tyrosine kinase belonging to the MET (MNNG HOS transforming
gene) family, and is expressed on the surfaces of various cells. Hepatocyte growth factor …
gene) family, and is expressed on the surfaces of various cells. Hepatocyte growth factor …
Mechanisms of HBV-induced hepatocellular carcinoma
M Levrero, J Zucman-Rossi - Journal of hepatology, 2016 - Elsevier
Hepatitis B virus (HBV) contributes to hepatocellular carcinoma (HCC) development through
direct and indirect mechanisms. HBV DNA integration into the host genome occurs at early …
direct and indirect mechanisms. HBV DNA integration into the host genome occurs at early …
Genetic landscape and biomarkers of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) has emerged as a major cause of cancer-related death. Its
mortality has increased in Western populations, with a minority of patients diagnosed at …
mortality has increased in Western populations, with a minority of patients diagnosed at …
The role of cancer-associated fibroblasts and fibrosis in liver cancer
S Affo, LX Yu, RF Schwabe - Annual Review of Pathology …, 2017 - annualreviews.org
Liver cancer is the second leading cause of cancer mortality worldwide, causing more than
700,000 deaths annually. Because of the wide landscape of genomic alterations and limited …
700,000 deaths annually. Because of the wide landscape of genomic alterations and limited …
Role of epithelial to mesenchymal transition in hepatocellular carcinoma
G Giannelli, P Koudelkova, F Dituri, W Mikulits - Journal of hepatology, 2016 - Elsevier
The epithelial to mesenchymal transition (EMT) is a multistep biological process whereby
epithelial cells change in plasticity by transient de-differentiation into a mesenchymal …
epithelial cells change in plasticity by transient de-differentiation into a mesenchymal …
Advances in targeted therapies for hepatocellular carcinoma in the genomic era
JM Llovet, A Villanueva, A Lachenmayer… - Nature reviews Clinical …, 2015 - nature.com
Mortality owing to liver cancer has increased in the past 20 years, and the latest estimates
indicate that the global health burden of this disease will continue to grow. Most patients with …
indicate that the global health burden of this disease will continue to grow. Most patients with …
Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts
F Calvo, N Ege, A Grande-Garcia, S Hooper… - Nature cell …, 2013 - nature.com
To learn more about cancer-associated fibroblasts (CAFs), we have isolated fibroblasts from
different stages of breast cancer progression and analysed their function and gene …
different stages of breast cancer progression and analysed their function and gene …
Molecular predictors of prevention of recurrence in HCC with sorafenib as adjuvant treatment and prognostic factors in the phase 3 STORM trial
Objective Sorafenib is the standard systemic therapy for advanced hepatocellular carcinoma
(HCC). Survival benefits of resection/local ablation for early HCC are compromised by 70 …
(HCC). Survival benefits of resection/local ablation for early HCC are compromised by 70 …
Glypican‐3: a promising biomarker for hepatocellular carcinoma diagnosis and treatment
Liver cancer is the second leading cause of cancer‐related deaths, and hepatocellular
carcinoma (HCC) is the most common type. Therefore, molecular targets are urgently …
carcinoma (HCC) is the most common type. Therefore, molecular targets are urgently …