Nucleic acid sensing machinery: targeting innate immune system for cancer therapy
S Iurescia, D Fioretti, M Rinaldi - Recent Patents on Anti …, 2018 - ingentaconnect.com
Background: Nucleic acid sensing is an essential strategy employed by the innate immune
system to detect both pathogen-derived nucleic acids and self-DNA released by host …
system to detect both pathogen-derived nucleic acids and self-DNA released by host …
Cyclic di-nucleotide compounds as sting agonists
MD Altman, W Chang, JN Cumming, R Liang… - US Patent …, 2018 - Google Patents
2017-01-30 Assigned to MERCK SHARP & DOHME CORP. reassignment MERCK SHARP
& DOHME CORP. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR …
& DOHME CORP. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR …
Cyclic dinucleotides useful for the treatment of inter alia cancer
K Biggadike, AC Champigny, DM Coe… - US Patent …, 2018 - Google Patents
A61K 31/7084 (2006. 01)(52) US Cl. CPC......... C07H 21/04 (2013. 01); A61K 31/7084
(2013. 01)(58) Field of Classification Search None See application file for complete search …
(2013. 01)(58) Field of Classification Search None See application file for complete search …
Cyclic di-nucleotides as modulators of STING
K Biggadike, AC Champigny, DM Coe… - US Patent …, 2019 - Google Patents
2012/0288515 AL 11/2012 Robbins et al. 2013/0266612 A1 10/2013 Fukasaka et al.
2014/0170689 A1 6/2014 Nesbitt et al. 2014/0205653 A1 7/2014 Dubensky, Jr. et al …
2014/0170689 A1 6/2014 Nesbitt et al. 2014/0205653 A1 7/2014 Dubensky, Jr. et al …
Cyclic di-nucleotide compounds as STING agonists
MD Altman, B Andresen, W Chang… - US Patent …, 2020 - Google Patents
2018-08-03 Assigned to MERCK SHARP & DOHME CORP. reassignment MERCK SHARP
& DOHME CORP. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR …
& DOHME CORP. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR …
Cyclic di-nucleotide compounds as sting agonists
MD Altman, B Andresen, W Chang… - US Patent …, 2020 - Google Patents
2018-08-06 Assigned to MERCK SHARP & DOHME CORP. reassignment MERCK SHARP
& DOHME CORP. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR …
& DOHME CORP. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR …
Cyclic di-nucleotide compounds as STING agonists
MD Altman, B Andresen, W Chang… - US Patent …, 2020 - Google Patents
(57) ABSTRACT A class of polycyclic compounds of general formula (II), of general formula
(II'), or of general formula (II"), wherein Base", Baseº. Y. Yº, X", X* X", X", X, X**, X", Xº", Rº, p …
(II'), or of general formula (II"), wherein Base", Baseº. Y. Yº, X", X* X", X", X, X**, X", Xº", Rº, p …
Cyclic di-nucleotide compounds as sting agonists
WL Wu, J Lim, JN Cumming, BW Trotter… - US Patent …, 2022 - Google Patents
US11466047B2 - Cyclic di-nucleotide compounds as sting agonists - Google Patents
US11466047B2 - Cyclic di-nucleotide compounds as sting agonists - Google Patents Cyclic …
US11466047B2 - Cyclic di-nucleotide compounds as sting agonists - Google Patents Cyclic …