Neuroscience of addiction: relevance to prevention and treatment

ND Volkow, M Boyle - American Journal of Psychiatry, 2018 - Am Psychiatric Assoc
Addiction, the most severe form of substance use disorder, is a chronic brain disorder
molded by strong biosocial factors that has devastating consequences to individuals and to …

Oxytocin for the treatment of drug and alcohol use disorders

MR Lee, EM Weerts - Behavioural pharmacology, 2016 - journals.lww.com
There is growing interest in the use of oxytocin (OT) as a potential treatment for alcohol and
other substance-use disorders. OT is a neuropeptide that modulates adaptive processes …

Rebalancing the addicted brain: oxytocin interference with the neural substrates of addiction

MT Bowen, ID Neumann - Trends in neurosciences, 2017 - cell.com
Drugs that act on the brain oxytocin (OXT) system may provide a much-needed treatment
breakthrough for substance-use disorders. Targeting the brain OXT system has the potential …

Pharmacotherapeutic agents in the treatment of methamphetamine dependence

KC Morley, JL Cornish, A Faingold… - Expert opinion on …, 2017 - Taylor & Francis
Introduction: Methamphetamine use is a serious public health concern in many countries
and is second to cannabis as the most widely abused illicit drug in the world. Effective …

The role of oxytocin in alcohol and drug abuse

CE King, A Gano, HC Becker - Brain research, 2020 - Elsevier
The neuropeptide oxytocin (OXT) plays a key role in adaptive processes associated with
reward, tolerance, memory and stress responses. Through interactions with brain reward …

Targeting the oxytocin system to treat addictive disorders: rationale and progress to date

MR Lee, MCH Rohn, G Tanda, L Leggio - CNS drugs, 2016 - Springer
The neuropeptide oxytocin plays a role in reward, stress, social affiliation, learning, and
memory processes. As such, there is increasing interest in oxytocin as a potential treatment …

Oxytocin and rodent models of addiction

KC Leong, S Cox, C King, H Becker… - International review of …, 2018 - Elsevier
Interest for the use of oxytocin as a treatment for addiction began over 40 years ago. Better
known for its roles in parturition, lactation and pair bonding, oxytocin also has anxiolytic …

The effect of chronic oxytocin treatment during abstinence from methamphetamine self-administration on incubation of craving, reinstatement, and anxiety

NA Everett, SJ Baracz, JL Cornish - Neuropsychopharmacology, 2020 - nature.com
Methamphetamine (METH) abuse is characterised by chronic relapse and anxiety, for which
there are no effective pharmacotherapies. Acute treatment with the neuropeptide oxytocin …

The impact of early life stress on the central oxytocin system and susceptibility for drug addiction: Applicability of oxytocin as a pharmacotherapy

SJ Baracz, NA Everett, JL Cornish - Neuroscience & Biobehavioral …, 2020 - Elsevier
Early life trauma is strongly associated with an increased vulnerability to abuse illicit drugs
and the impairment of neural development. This includes alterations to the development of …

Oxytocin signaling in the treatment of drug addiction: Therapeutic opportunities and challenges

X Che, J Cai, Y Liu, T Xu, J Yang, C Wu - Pharmacology & therapeutics, 2021 - Elsevier
Drug addiction is one of the leading causes of mortality worldwide. Despite great advances
were achieved in understanding the neurobiology of drug addiction, the therapeutic options …