Molecular farming–the slope of enlightenment
Molecular farming can be defined as the use of plants to produce recombinant protein
products. The technology is now> 30 years old. The early promise of molecular farming was …
products. The technology is now> 30 years old. The early promise of molecular farming was …
Recent advances towards development and commercialization of plant cell culture processes for the synthesis of biomolecules
SA Wilson, SC Roberts - Plant biotechnology journal, 2012 - Wiley Online Library
Plant cell culture systems were initially explored for use in commercial synthesis of several
high‐value secondary metabolites, allowing for sustainable production that was not limited …
high‐value secondary metabolites, allowing for sustainable production that was not limited …
Plant-made vaccine antigens and biopharmaceuticals
Plant cells are ideal bioreactors for the production and oral delivery of vaccines and
biopharmaceuticals, eliminating the need for expensive fermentation, purification, cold …
biopharmaceuticals, eliminating the need for expensive fermentation, purification, cold …
Advances in plant molecular farming
OO Obembe, JO Popoola, S Leelavathi… - Biotechnology advances, 2011 - Elsevier
Plant molecular farming (PMF) is a new branch of plant biotechnology, where plants are
engineered to produce recombinant pharmaceutical and industrial proteins in large …
engineered to produce recombinant pharmaceutical and industrial proteins in large …
[HTML][HTML] Lysosomal storage diseases: diagnostic confirmation and management of presymptomatic individuals
Purpose To develop educational guidelines for the diagnostic confirmation and
management of individuals identified by newborn screening, family-based testing after …
management of individuals identified by newborn screening, family-based testing after …
Towards high-yield production of pharmaceutical proteins with plant cell suspension cultures
“Molecular farming” in plants with significant advantages in cost and safety is touted as a
promising platform for the production of complex pharmaceutical proteins. While whole-plant …
promising platform for the production of complex pharmaceutical proteins. While whole-plant …
Lysosomal enzyme replacement therapies: Historical development, clinical outcomes, and future perspectives
Lysosomes and lysosomal enzymes play a central role in numerous cellular processes,
including cellular nutrition, recycling, signaling, defense, and cell death. Genetic deficiencies …
including cellular nutrition, recycling, signaling, defense, and cell death. Genetic deficiencies …
GMP issues for recombinant plant-derived pharmaceutical proteins
R Fischer, S Schillberg, S Hellwig, RM Twyman… - Biotechnology …, 2012 - Elsevier
Recombinant proteins can be produced in a diverse array of plant-based systems, ranging
from whole plants growing in the soil to plant suspension cells growing in a fully-defined …
from whole plants growing in the soil to plant suspension cells growing in a fully-defined …
Seed‐based expression systems for plant molecular farming
J Boothe, C Nykiforuk, Y Shen… - Plant Biotechnology …, 2010 - Wiley Online Library
The evolution of the seed system provides enormous adaptability to the gymnosperms and
angiosperms, because of the properties of dormancy, nutrient storage and seedling vigour …
angiosperms, because of the properties of dormancy, nutrient storage and seedling vigour …
Pivotal trial with plant cell–expressed recombinant glucocerebrosidase, taliglucerase alfa, a novel enzyme replacement therapy for Gaucher disease
A Zimran, E Brill-Almon, R Chertkoff… - Blood, The Journal …, 2011 - ashpublications.org
Abstract Taliglucerase alfa (Protalix Biotherapeutics, Carmiel, Israel) is a novel plant cell–
derived recombinant human β-glucocerebrosidase for Gaucher disease. A phase 3, double …
derived recombinant human β-glucocerebrosidase for Gaucher disease. A phase 3, double …