Oxidative stress (OS), defined as disturbances in the pro-/antioxidant balance, is harmful to
cells due to the excessive generation of highly reactive oxygen (ROS) and nitrogen (RNS) …

Hemodialysis (HD) patients are at high risk for all‐cause mortality and cardiovascular
events. In addition to traditional risk factors, excessive oxidative stress (OS) and chronic …

Neutrophilic polymorphonuclear leukocytes (neutrophils) are highly specialized for their
primary function, the phagocytosis and destruction of microorganisms. When coated with …

Accelerated cardiovascular disease is a frequent complication of renal disease. Chronic
kidney disease promotes hypertension and dyslipidemia, which in turn can contribute to the …

Protein-energy malnutrition (PEM) and inflammation are common and usually concurrent in
maintenance dialysis patients. Many factors that appear to lead to these 2 conditions …

Introduction. Patients affected by end‐stage renal disease (ESRD) experience an excess of
morbidity and mortality due to cardiovascular disease (CVD), which cannot be fully …

Myeloperoxidase (MPO) is a leukocyte-derived enzyme that catalyzes the formation of a
number of reactive oxidant species. In addition to being an integral component of the innate …

In recent studies we demonstrated that systemic levels of protein-bound nitrotyrosine
(NO2Tyr) and myeloperoxidase (MPO), a protein that catalyzes generation of nitrating …

Myeloperoxidase (MPO), a heme protein abundantly expressed in polymorphonuclear
neutrophils (PMN), has long been viewed to function primarily as a bactericidal enzyme …

High density lipoprotein (HDL) has many properties, which contribute to its atheroprotective
role. However, some recent clinical trials have identified subjects with the progression of …