Weight gain and integrase inhibitors

AR Eckard, GA McComsey - Current opinion in infectious diseases, 2020 - journals.lww.com
Although INSTI-based regimens are highly efficacious for viral suppression, they appear to
cause more weight gain and treatment emergent obesity than non-INSTI-based regimens …

HIV infection and coronary heart disease: mechanisms and management

PY Hsue, DD Waters - Nature Reviews Cardiology, 2019 - nature.com
Antiretroviral therapy has largely transformed HIV infection into a chronic disease condition.
As such, physicians and other providers caring for individuals living with HIV infection need …

Antiretroviral drugs for treatment and prevention of HIV infection in adults: 2016 recommendations of the International Antiviral Society–USA panel

HF Günthard, MS Saag, CA Benson, C Del Rio, JJ Eron… - Jama, 2016 - jamanetwork.com
Importance New data and therapeutic options warrant updated recommendations for the use
of antiretroviral drugs (ARVs) to treat or to prevent HIV infection in adults. Objective To …

Brief report: weight gain in persons with HIV switched from efavirenz-based to integrase strand transfer inhibitor–based regimens

J Norwood, M Turner, C Bofill, P Rebeiro… - JAIDS Journal of …, 2017 - journals.lww.com
Background: With the introduction of integrase strand transfer inhibitor (INSTI)-based
antiretroviral therapy, persons living with HIV have a potent new treatment option. Recently …

A review of non-alcoholic fatty liver disease in HIV-infected patients: the next big thing?

BJ van Welzen, T Mudrikova, A El Idrissi… - Infectious diseases and …, 2019 - Springer
The burden of liver-related morbidity remains high among HIV-infected patients, despite
advances in the treatment of HIV and viral hepatitis. Especially, the impact of non-alcoholic …

Cardiovascular implications of immune disorders in women

CA Moran, LF Collins, N Beydoun, PK Mehta… - Circulation …, 2022 - Am Heart Assoc
Immune responses differ between men and women, with women at higher risk of developing
chronic autoimmune diseases and having more robust immune responses to many viruses …

Changes in waist circumference in HIV-infected individuals initiating a raltegravir or protease inhibitor regimen: effects of sex and race

P Bhagwat, I Ofotokun, GA McComsey… - Open forum …, 2018 - academic.oup.com
Background This study investigates the association of clinical and demographic predictors
with abdominal fat gain, measured using waist circumference (WC) and self-reported …

Cytokines and T-cell homeostasis in HIV infection

ML Freeman, CL Shive, TP Nguyen… - The Journal of …, 2016 - academic.oup.com
Untreated human immunodeficiency virus (HIV) infection is characterized by progressive
CD4+ T-cell depletion and CD8+ T-cell expansion, and CD4+ T-cell depletion is linked …

Physical activity and exercise to improve cardiovascular health for adults living with HIV

C Ozemek, KM Erlandson, CM Jankowski - Progress in cardiovascular …, 2020 - Elsevier
Pharmacologic advancements in the treatment of human immunodeficiency virus (HIV) has
extended the life expectancy of people living with HIV (PLWH). An unfortunate side effect of …

Senescent phenotype induced by p90RSK-NRF2 signaling sensitizes monocytes and macrophages to oxidative stress in HIV-positive individuals: Implications for …

MV Singh, S Kotla, NT Le, K Ae Ko, KS Heo, Y Wang… - Circulation, 2019 - Am Heart Assoc
Background: The incidence of cardiovascular disease is higher in HIV-positive (HIV+)
patients than it is in the average population, and combination antiretroviral therapy (cART) is …