Terpene synthases as metabolic gatekeepers in the evolution of plant terpenoid chemical diversity
PS Karunanithi, P Zerbe - Frontiers in plant science, 2019 - frontiersin.org
Terpenoids comprise tens of thousands of small molecule natural products that are widely
distributed across all domains of life. Plants produce by far the largest array of terpenoids …
distributed across all domains of life. Plants produce by far the largest array of terpenoids …
[HTML][HTML] Cytochrome P450 enzymes: a driving force of plant diterpene diversity
In plant terpene biosynthesis, oxidation of the hydrocarbon backbone produced by terpene
synthases is typically carried out by cytochrome P450 oxygenases (CYPs). The …
synthases is typically carried out by cytochrome P450 oxygenases (CYPs). The …
Large chromosomal deletions and heritable small genetic changes induced by CRISPR/Cas9 in rice
H Zhou, B Liu, DP Weeks, MH Spalding… - Nucleic acids …, 2014 - academic.oup.com
The Cas9/sgRNA of the CRISPR/Cas system has emerged as a robust technology for
targeted gene editing in various organisms, including plants, where Cas9/sgRNA-mediated …
targeted gene editing in various organisms, including plants, where Cas9/sgRNA-mediated …
Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism
Plant metabolites are important to world food security in terms of maintaining sustainable
yield and providing food with enriched phytonutrients. Here we report comprehensive …
yield and providing food with enriched phytonutrients. Here we report comprehensive …
Plant metabolic clusters–from genetics to genomics
Plant natural products are of great value for agriculture, medicine and a wide range of other
industrial applications. The discovery of new plant natural product pathways is currently …
industrial applications. The discovery of new plant natural product pathways is currently …
The emerging role of biosynthetic gene clusters in plant defense and plant interactions
G Polturak, A Osbourn - PLoS pathogens, 2021 - journals.plos.org
The plant kingdom produces a diverse array of chemicals, collectively making an estimated
105 to 106 different metabolites [1, 2]. These compounds are either known or likely to have …
105 to 106 different metabolites [1, 2]. These compounds are either known or likely to have …
Plant metabolic gene clusters in the multi-omics era
Secondary metabolism in plants gives rise to a vast array of small-molecule natural
products. The discovery of operon-like gene clusters in plants has provided a new …
products. The discovery of operon-like gene clusters in plants has provided a new …
Integrated omics analysis of specialized metabolism in medicinal plants
Medicinal plants are a rich source of highly diverse specialized metabolites with important
pharmacological properties. Until recently, plant biologists were limited in their ability to …
pharmacological properties. Until recently, plant biologists were limited in their ability to …
CYP76AH1 catalyzes turnover of miltiradiene in tanshinones biosynthesis and enables heterologous production of ferruginol in yeasts
Cytochrome P450 enzymes (CYPs) play major roles in generating highly functionalized
terpenoids, but identifying the exact biotransformation step (s) catalyzed by plant CYP in …
terpenoids, but identifying the exact biotransformation step (s) catalyzed by plant CYP in …
The birth, evolution and death of metabolic gene clusters in fungi
Fungi contain a remarkable diversity of both primary and secondary metabolic pathways
involved in ecologically specialized or accessory functions. Genes in these pathways are …
involved in ecologically specialized or accessory functions. Genes in these pathways are …