The role of amino acids in endothelial biology and function

M Li, Y Wu, L Ye - Cells, 2022 - mdpi.com
The vascular endothelium acts as an important component of the vascular system. It is a
barrier between the blood and vessel wall. It plays an important role in regulating blood …

SGLT2 Inhibitors: New Hope for the Treatment of Acute Myocardial Infarction?

YJ Wu, SB Wang, LS Wang - American Journal of Cardiovascular Drugs, 2022 - Springer
Among all of the new antidiabetic drugs, an increasing number of studies have evaluated
the relationship between the sodium-glucose cotransporter 2 inhibitors (SGLT2i) and acute …

Empagliflozin improves post-infarction cardiac remodeling through GTP enzyme cyclohydrolase 1 and irrespective of diabetes status

MC Asensio Lopez, A Lax, A Hernandez Vicente… - Scientific Reports, 2020 - nature.com
Abstract Sodium-glucose co-transporter-2 inhibitors (SGLT2i) have shown to prevent heart
failure progression, although the mechanisms remain poorly understood. Here we evaluated …

Antihypertensive Activity of Milk Fermented by Lactiplantibacillus plantarum SR37-3 and SR61-2 in L-NAME-Induced Hypertensive Rats

L Yuan, Y Li, M Chen, L Xue, J Wang, Y Ding, J Zhang… - Foods, 2022 - mdpi.com
Probiotic fermented milk can lower the incidence rate of hypertension and is beneficial to the
regulation of the intestinal microecology. However, the underlying molecular mechanism …

Chemoradiation therapy changes oral microbiome and metabolomic profiles in patients with oral cavity cancer and oropharyngeal cancer

Y Lim, KD Tang, AV Karpe, DJ Beale, M Totsika… - Head & …, 2021 - Wiley Online Library
Background Patients with oral cavity cancer (OCC) and oropharyngeal cancer (OPC) are
often seen with locoregionally advanced disease requiring complex multimodality …

L-phenylalanine attenuates high salt-induced hypertension in Dahl SS rats through activation of GCH1-BH4

Z Wang, C Cheng, X Yang, C Zhang - PLoS One, 2021 - journals.plos.org
Amino acid metabolism plays an important role in controlling blood pressure by regulating
the production of NO and ROS. The present study examined amino acid levels in the serum …

Comparison of the Chemical Components, Efficacy and Mechanisms of Action of Chrysanthemum morifolium Flower and Its Wild Relative Chrysanthemum indicum …

Y Wang, Y Li, W Guo, X Yang, J Qu, M Gao… - International Journal of …, 2022 - mdpi.com
To clarify the differences in the clinical application scope of Chrysanthemum morifolium
flower (CMF) and Chrysanthemum indicum flower (CIF), two herbs of similar origin, an …

Effects of gene polymorphisms on delayed MTX clearance, toxicity, and metabolomic changes after HD-MTX treatment in children with acute lymphoblastic leukemia

Y Zhou, H He, L Ding, T Wang, X Liu, M Zhang… - European Journal of …, 2024 - Springer
This study aims to assess the role of methotrexate-related gene polymorphisms in children
with acute lymphoblastic leukemia (ALL) during high-dose methotrexate (HD-MTX) therapy …

Antihypertensive effect and underlying mechanism of tripeptide NCW on spontaneously hypertensive rats using metabolomics analysis

S Wu, W Zhao, Z Yu, J Liu - Food & Function, 2022 - pubs.rsc.org
Tripeptide NCW identified in our previous study displayed a strong ACE inhibitory activity,
but whether it has any antihypertensive effect in vivo remains unknown. Thus, in this study …

Characterization of anaphylaxis reveals different metabolic changes depending on severity and triggers

C Perales‐Chorda, D Obeso, L Twomey… - Clinical & …, 2021 - Wiley Online Library
Background Despite the increasing incidence of anaphylaxis, its underlying molecular
mechanisms and biomarkers for appropriate diagnosis remain undetermined. The rapid …