Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …

The lysosomal degradation pathway of autophagy plays a fundamental role in cellular,
tissue, and organismal homeostasis and is mediated by evolutionarily conserved autophagy …

Macroautophagy is an evolutionarily conserved process that delivers diverse cellular
contents to lysosomes for degradation. As our understanding of this pathway grows, so does …

The cardinal stages of macroautophagy are driven by core autophagy‐related (ATG)
proteins, whose ablation largely abolishes intracellular turnover. Disrupting ATG genes is …

Autophagy is a conserved catabolic process that degrades cytoplasmic constituents and
organelles in the lysosome. Starvation-induced protein degradation is a salient feature of …

The concept of macroautophagy was established in 1963, soon after the discovery of
lysosomes in rat liver. Over the 50 years since, studies of liver autophagy have produced …

The mammalian brain depends upon glucose as its main source of energy, and tight
regulation of glucose metabolism is critical for brain physiology. Consistent with its critical …

Abstract Knowledge gained over the past 10 years about the mechanisms that underpin
autophagy has provided a universal framework for studies of diverse physiological and …

Autophagy represents a key regulator of aging and metabolism in sensing energy
deprivation. We find that fasting in mice activates autophagy in the liver paralleled by …

With the steady rise in the prevalence of obesity and its associated diseases, research
aimed at understanding the mechanisms that regulate and control whole body energy …