For 50 years the term 'gene'has been synonymous with regions of the genome encoding
mRNAs that are translated into protein. However, recent genome‐wide studies have shown …

A recent revolution in RNA biology has led to the identification of new RNA classes with
unanticipated functions, new types of RNA modifications, an unexpected multiplicity of …

To combat hostile viruses, bacteria and archaea have evolved a unique antiviral defense
system composed of clustered regularly interspaced short palindromic repeats (CRISPRs) …

Genome-wide genetic approaches have proven useful for examining pathways of biological
significance in model organisms such as Saccharomyces cerevisiae, Drosophila …

Small interfering RNAs (siRNAs) are the mediators of mRNA degradation in the process of
RNA interference (RNAi). Here, we describe a human biochemical system that recapitulates …

Among the 3 billion base pairs of the human genome, there are∼ 30,000–40,000 protein-
coding genes, but the function of at least half of them remains unknown. A new tool—short …

During recent decades there have been remarkable advances in biology, in which one of
the most important discoveries is RNA interference (RNAi). RNAi is a specific post …

RNA interference (RNAi) was discovered less than a decade ago and already there are
human clinical trials in progress or planned. A major advantage of RNAi versus other …

Since the first description of RNA interference (RNAi) in animals less than a decade ago,
there has been rapid progress towards its use as a therapeutic modality against human …

With increasing knowledge on the molecular mechanisms of endogenous RNA interference,
small interfering RNAs (siRNAs) have been emerging as innovative nucleic acid medicines …