Poly (ADP-ribosyl) ation (PARylation) is an essential post-translational modification
catalyzed by poly (ADP-ribose) polymerase (PARP) enzymes. Poly (ADP-ribose) …

Aims Poly (ADP-ribose) polymerase-(PARP)-1 is predominantly triggered by DNA damage.
Overexpression of PARP-1 is known for its association with the pathogenesis of several …

The proteins within the Poly-ADP Ribose Polymerase (PARP) family encompass a diverse
and integral set of cellular functions. PARP1 and PARP2 have been extensively studied for …

Major advances have recently defined functions for human mono-ADP-ribosylating PARP
enzymes (mono-ARTs), also opening up potential applications for targeting them to treat …

Due to cell-cycle dysregulation, many cancer cells contain more than the normal compliment
of centrosomes, a state referred to as centrosome amplification (CA). CA can drive …

Proteins interacting with ADP-ribosyl groups are often involved in disease-related pathways
or viral infections, making them attractive drug targets. We present a robust and accessible …

ADP-ribosylation is a reversible post-translational modification (PTM) tightly regulated by the
dynamic interplay between its writers, readers and erasers. As an intricate and versatile …

Among the post-translational modifications of proteins, ADP-ribosylation has been studied
for over fifty years, and a large set of functions, including DNA repair, transcription, and cell …

Poly-ADP-ribose polymerases (PARPs) are a family of enzymes responsible for transferring
individual or chains of ADP-ribose subunits to substrate targets as a type of post …

We report [1, 2, 4] triazolo [3, 4-b] benzothiazole (TBT) as a new inhibitor scaffold, which
competes with nicotinamide in the binding pocket of human poly-and mono-ADP …