The innate immune response provides the first line of defense against invading pathogens,
and immune disorders cause a variety of diseases. The fruit fly Drosophila melanogaster …

In this FlyBook chapter, we present a survey of the current literature on the development of
the hematopoietic system in Drosophila. The Drosophila blood system consists entirely of …

The identification of the Drosophila melanogaster Toll pathway cascade and the subsequent
characterization of TLRs have reshaped our understanding of the immune system. Ever …

To combat infection, the fruit fly Drosophila melanogaster relies on multiple innate defense
reactions, many of which are shared with higher organisms. These reactions include the use …

The innate immune system of insects is divided into humoral defenses that include the
production of soluble effector molecules and cellular defenses like phagocytosis and …

Here, we show that the major mosquito vector for dengue virus uses the JAK-STAT pathway
to control virus infection. Dengue virus infection in Aedes aegypti mosquitoes activates the …

Summary The Janus kinase (Jak) family is one of ten recognized families of non-receptor
tyrosine kinases. Mammals have four members of this family, Jak1, Jak2, Jak3 and Tyrosine …

High levels of interspecies conservation characterise all signal transduction cascades and
demonstrate the significance of these pathways over evolutionary time. Here, we review …

We review recent advances in our understanding of the mechanisms of insect immune
defence, but do so in a framework defined by the ecological and evolutionary forces that …

Drosophila hematopoiesis occurs in a specialized organ called the lymph gland. In this
systematic analysis of lymph gland structure and gene expression, we define the …