At present, the legendary magic bullet, ie, a drug with high potency and selectivity toward a
specific biological target, shares the spotlight with an emerging and alternative …

Protein kinases are key components in cellular signaling pathways as they carry out the
phosphorylation of proteins, primarily on Ser, Thr, and Tyr residues. The catalytic activity of …

Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a heterotrimeric αβγ
complex that functions as a central regulator of energy homeostasis. Energy stress manifests …

Fragment-based drug discovery (FBDD) is well suited for discovering both drug leads and
chemical probes of protein function; it can cover broad swaths of chemical space and allows …

Lung cancer has a high prevalence, with a growing number of new cases and mortality
every year. Furthermore, the survival rate of patients with non-small-cell lung carcinoma …

The presence of druggable, topographically distinct allosteric sites on a wide range of
receptor families has offered new paradigms for small molecules to modulate receptor …

The modulation of kinase function has become an important goal in modern drug discovery
and chemical biology research. In cancer-targeted therapies, kinase inhibitors have been …

Allostery is a fundamental and extensive mechanism of intramolecular signal transmission.
Allosteric drugs possess several unique pharmacological advantages over traditional …

Dual-targeting therapeutics by coadministration of allosteric and orthosteric drugs is drawing
increased attention as a revolutionary strategy for overcoming the drug-resistance problems …

Previously, we have reported a new biomolecular phenomenon spanning between protein
folding and binding, termed as self-binding peptides (SBPs), where a short peptide segment …