The blood–brain barrier is playing a critical role in controlling the influx and efflux of
biological substances essential for the brain's metabolic activity as well as neuronal function …

Snail1 is the founding member of the Snail superfamily of zinc-finger transcription factors,
which also includes Snail2 (Slug) and Snail3 (Smuc). The superfamily is involved in cell …

The Blood–brain barrier (BBB), present at the level of the endothelium of cerebral blood
vessels, selectively restricts the blood-to-brain paracellular diffusion of compounds; it is …

The blood–brain barrier (BBB) is a diffusion barrier, which impedes influx of most
compounds from blood to brain. Three cellular elements of the brain microvasculature …

Tight junctions are one mode of cell–cell adhesion in epithelial and endothelial cellular
sheets. They act as a primary barrier to the diffusion of solutes through the intercellular …

Occludin is the only known integral membrane protein localizing at tight junctions (TJ), but
recent targeted disruption analysis of the occludin gene indicated the existence of as yet …

Intercellular tight junctions (TJs) exhibit a complex molecular architecture involving the
regulated cointeraction of cytoplasmic adaptor proteins (eg, zonula occludens) and integral …

The microvascular endothelial cell monolayer localized at the critical interface between the
blood and vessel wall has the vital functions of regulating tissue fluid balance and supplying …

The tight junction (TJ) and its adhesion molecules, claudins, are responsible for the barrier
function of simple epithelia, but TJs have not been thought to play an important role in the …

Intercellular junctions mediate adhesion and communication between adjoining endothelial
and epithelial cells. In the endothelium, junctional complexes comprise tight junctions …