In mammals, hundreds of proteins use iron in a multitude of cellular functions, including vital
processes such as mitochondrial respiration, gene regulation and DNA synthesis or repair …

200 billion red blood cells (RBCs) are produced every day, requiring more than 2× 10 15
iron atoms every second to maintain adequate erythropoiesis. These numbers translate into …

Introduction: Mitochondria are cellular organelles that perform numerous bioenergetic,
biosynthetic, and regulatory functions and play a central role in iron metabolism …

Disruptions in iron homeostasis from both iron deficiency and overload account for some of
the most common human diseases. Iron metabolism is balanced by two regulatory systems …

Iron is a crucial transition metal for virtually all life. Two major destinations of iron within
mammalian cells are the cytosolic iron-storage protein, ferritin, and mitochondria. In …

Iron is an essential but potentially hazardous biometal. Mammalian cells require sufficient
amounts of iron to satisfy metabolic needs or to accomplish specialized functions. Iron is …

Iron is vital for almost all organisms because of its ability to donate and accept electrons with
relative ease. It serves as a cofactor for many proteins and enzymes necessary for oxygen …

Heme (iron-protoporphyrin IX) is an essential co-factor involved in multiple biological
processes: oxygen transport and storage, electron transfer, drug and steroid metabolism …

Abnormal accumulation of brain iron has been detected in various neurodegenerative
diseases, but the contribution of iron overload to pathology remains unclear. In a group of …

BACKGROUND: Iron is utilized by several proteins as cofactor for major biological
processes. However, iron may also harm cells by catalyzing the generation of free radicals …