Innate and adaptive immunity during SARS-CoV-2 infection: biomolecular cellular markers and mechanisms

B Brown, V Ojha, I Fricke, SA Al-Sheboul, C Imarogbe… - Vaccines, 2023 - mdpi.com
The coronavirus 2019 (COVID-19) pandemic was caused by a positive sense single-
stranded RNA (ssRNA) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

The role of lung macrophages in acute respiratory distress syndrome

W Dang, Y Tao, X Xu, H Zhao, L Zou, Y Li - Inflammation Research, 2022 - Springer
Acute respiratory distress syndrome (ARDS) is an acute and diffuse inflammatory lung injury
in a short time, one of the common severe manifestations of the respiratory system that …

Multiplexed discrimination of SARS-CoV-2 variants via plasmonic-enhanced fluorescence in a portable and automated device

Y Liu, Y Yang, G Wang, D Wang, PL Shao… - Nature Biomedical …, 2023 - nature.com
Portable assays for the rapid identification of lineages of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) are needed to aid large-scale efforts in monitoring the …

Circulating microRNA signatures associated with disease severity and outcome in COVID-19 patients

A Giannella, S Riccetti, A Sinigaglia, C Piubelli… - Frontiers in …, 2022 - frontiersin.org
Background SARS-CoV-2 induces a spectrum of clinical conditions ranging from
asymptomatic infection to life threatening severe disease. Host microRNAs have been …

[HTML][HTML] Manifestations and mechanism of SARS-CoV2 mediated cardiac injury

S Xu, W Wu, S Zhang - International Journal of Biological Sciences, 2022 - ncbi.nlm.nih.gov
Abstract Coronavirus disease 2019 (COVID-19), a global pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV2) had resulted in considerable morbidity …

[HTML][HTML] Targeting immune-fibroblast crosstalk in myocardial infarction and cardiac fibrosis

JM Amrute, X Luo, V Penna, A Bredemeyer… - Research …, 2023 - ncbi.nlm.nih.gov
Inflammation and tissue fibrosis co-exist and are causally linked to organ dysfunction.
However, the molecular mechanisms driving immune-fibroblast crosstalk in human cardiac …

Type I interferons induce an epigenetically distinct memory B cell subset in chronic viral infection

L Cooper, H Xu, J Polmear, L Kealy, C Szeto, ES Pang… - Immunity, 2024 - cell.com
Memory B cells (MBCs) are key providers of long-lived immunity against infectious disease,
yet in chronic viral infection, they do not produce effective protection. How chronic viral …

Severe COVID-19 is characterised by inflammation and immature myeloid cells early in disease progression

L Townsend, AH Dyer, A Naughton, S Imangaliyev… - Heliyon, 2022 - cell.com
SARS-CoV-2 infection causes a wide spectrum of disease severity. Identifying the
immunological characteristics of severe disease and the risk factors for their development …

SARS-CoV-2 inflammation durably imprints memory CD4 T cells

SL Gray-Gaillard, SM Solis, HM Chen, C Monteiro… - Science …, 2024 - science.org
Memory CD4 T cells are critical to human immunity, yet it is unclear whether viral
inflammation during memory formation has long-term consequences. Here, we compared …

Defining cardiac functional recovery in end-stage heart failure at single-cell resolution

JM Amrute, L Lai, P Ma, AL Koenig… - Nature cardiovascular …, 2023 - nature.com
Recovery of cardiac function is the holy grail of heart failure therapy yet is infrequently
observed and remains poorly understood. In this study, we performed single-nucleus RNA …