Cryptococcus neoformans and Cryptococcus gattii species complexes cause
meningoencephalitis with high fatality rates and considerable morbidity, particularly in …

Key Points Cryptococcal Disease in Diverse Hosts Worldwide, cryptococcal meningitis kills
up to 180,000 persons annually and is the most common cause of nonviral meningitis in the …

Cryptococcal meningitis is a leading cause of morbidity and mortality globally, especially in
people with advanced HIV disease. Cryptococcal meningitis is responsible for nearly 20% of …

Background Amphotericin B is the gold standard treatment for severe mycoses. A new orally
delivered, less-toxic formulation of amphotericin has been developed. Methods In our …

Invasive fungal infections continue to increase as at-risk populations expand. The high
associated morbidity and mortality with fungal diseases mandate the continued investigation …

Cryptococcal meningoencephalitis was first described over a century ago. This fungal
infection is preventable and treatable yet continues to be associated with excessive …

Abstract The AmBisome Therapy Induction Optimization (AMBITION-cm) trial, conducted in
eastern and southern Africa, showed that a single, high dose (10 mg/kg) of liposomal …

Cryptococcosis causes a high burden of disease worldwide. This systematic review
summarizes the literature on Cryptococcus neoformans and C. gattii infections to inform the …

Cryptococcal Meningitis (CM) is uniformly fatal if not treated, and treatment options are
limited. We previously reported on the activity of APX2096, the prodrug of the novel Gwt1 …

Background Limited data exist on the antifungal activity of daily liposomal amphotericin B
with flucytosine induction regimens for cryptococcal meningitis, which are recommended in …