Fold-switching proteins respond to cellular stimuli by remodeling their secondary structures
and changing their functions. Whereas several previous reviews have focused on various …

Since the proposal of Anfinsen's thermodynamic hypothesis in 1963, our understanding of
protein folding and dynamics has gained significant appreciation of its nuance and …

A central tenet of biology is that globular proteins have a unique 3D structure under
physiological conditions. Recent work has challenged this notion by demonstrating that …

Protein patterning is vital for many fundamental cellular processes. This raises two intriguing
questions: Can such intrinsically complex processes be reduced to certain core principles …

Every amino acid exhibits a different propensity for distinct structural conformations. Hence,
decoding how the primary amino acid sequence undergoes the transition to a defined …

This work highlights the relevant contribution of conformational stereoisomers to the
complexity and functions of any molecular compound. Conformers have the same molecular …

The numerous interconnected biochemical pathways that make up the metabolism of a
living cell comprise a fuzzy logic system because of its high level of complexity and our …

The CLIC proteins are a highly conserved family of metazoan proteins with the unusual
ability to adopt both soluble and integral membrane forms. The physiological functions of …

Four de novo proteins differing in single mutation positions, with a chain length of 56 amino
acids, represent diverse 3D structures: monomeric 3α and 4β+ α folds. The reason for this …

Evolutionary innovations are often achieved by repurposing existing genes to perform new
functions; however, the mechanisms enabling the transition from old to new remain …