Janus tyrosine kinase (JAK) family of proteins have been identified as crucial proteins in
signal transduction initiated by a wide range of membrane receptors. Among the proteins in …

Breast cancer is the most commonly diagnosed cancer and second-leading cause of cancer
deaths in women. Breast cancer stem cells (BCSCs) promote metastasis and therapeutic …

NAD+ metabolism is implicated in aging and cancer. However, its role in immune checkpoint
regulation and immune evasion remains unclear. Here, we find nicotinamide …

Type I interferon responses are considered the primary means by which viral infections are
controlled in mammals. Despite this view, several pathogens activate antiviral responses in …

Several immune suppressive mechanisms that evade the host immune response have been
described in patients with hepatocellular carcinoma (HCC); one of these mechanisms is …

Considerable progress has been made in the development of anticancer agents over the
past few decades, and a lot of new anticancer agents from natural and synthetic sources …

Besides their microbicidal functions, human β-defensins (hBD) and LL-37 activate different
immune and inflammatory cells, and their expression is enhanced in inflamed skin and …

Fibrosis is a common and intractable condition associated with various pathologies. It is
characterized by accumulation of an excessive amount of extracellular matrix molecules that …

Cardiovascular diseases (CVDs) are serious public health issues and are responsible for
nearly one-third of global deaths. Mitochondrial dysfunction is accountable for the …

Globally suppressed T-cell function has been described in many patients with cancer to be a
major hurdle for the development of clinically efficient cancer immunotherapy. Inhibition of …