What are the neurotoxins in hemotoxic snake venoms?

A Osipov, Y Utkin - International journal of molecular sciences, 2023 - mdpi.com
Snake venoms as tools for hunting are primarily aimed at the most vital systems of the prey,
especially the nervous and circulatory systems. In general, snakes of the Elapidae family …

Cysteine-rich secretory proteins (CRISPs) from venomous snakes: An overview of the functional diversity in a large and underappreciated superfamily

T Tadokoro, C M. Modahl, K Maenaka, N Aoki-Shioi - Toxins, 2020 - mdpi.com
The CAP protein superfamily (Cysteine-rich secretory proteins (CRISPs), Antigen 5 (Ag5),
and Pathogenesis-related 1 (PR-1) proteins) is widely distributed, but for toxinologists …

Amplification of snake venom toxicity by endogenous signaling pathways

PE Bickler - Toxins, 2020 - mdpi.com
The active components of snake venoms encompass a complex and variable mixture of
proteins that produce a diverse, but largely stereotypical, range of pharmacologic effects and …

The venom composition of the snake tribe Philodryadini:'Omic'techniques reveal intergeneric variability among South American racers

EC Tioyama, JD Bayona-Serrano, JA Portes-Junior… - Toxins, 2023 - mdpi.com
Snakes of the Philodryadini tribe are included in the Dipsadidae family, which is a diverse
group of rear-fanged snakes widespread in different ecological conditions, including …

Venoms of rear-fanged snakes: new proteins and novel activities

CM Modahl, SP Mackessy - Frontiers in Ecology and Evolution, 2019 - frontiersin.org
Snake venom research has focused on front-fanged venomous snakes because of the high
incidence of human morbidity and mortality from envenomations and larger venom yields of …

An overview of Phoneutria nigriventer spider venom using combined transcriptomic and proteomic approaches

MRV Diniz, ALB Paiva, C Guerra-Duarte… - PloS one, 2018 - journals.plos.org
Phoneutria nigriventer is one of the largest existing true spiders and one of the few
considered medically relevant. Its venom contains several neurotoxic peptides that act on …

The functions of CAP superfamily proteins in mammalian fertility and disease

AS Gaikwad, J Hu, DG Chapple… - Human reproduction …, 2020 - academic.oup.com
BACKGROUND Members of the cysteine-rich secretory proteins (CRISPS), antigen 5 (Ag5)
and pathogenesis-related 1 (Pr-1)(CAP) superfamily of proteins are found across the …

[HTML][HTML] Cytotoxic and inflammatory potential of a phospholipase A2 from Bothrops jararaca snake venom

RCA Cedro, DL Menaldo, TR Costa… - Journal of Venomous …, 2018 - SciELO Brasil
Background: Snake venom phospholipases A2 (PLA2s) have been reported to induce
myotoxic, neurotoxic, hemolytic, edematogenic, cytotoxic and proinflammatory effects. This …

Affected inflammation-related signaling pathways in snake envenomation: A recent insight

P Luo, Y Ji, X Liu, W Zhang, R Cheng, S Zhang, X Qian… - Toxicon, 2023 - Elsevier
Snake envenomation is well known to cause grievous pathological signs, including
haemorrhagic discharge, necrosis, and respiratory distress. However, inflammatory …

Integrating Top-Down and Bottom-Up Mass Spectrometric Strategies for Proteomic Profiling of Iranian Saw-Scaled Viper, Echis carinatus sochureki, Venom

P Ghezellou, W Albuquerque, V Garikapati… - Journal of proteome …, 2020 - ACS Publications
Saw-scaled or carpet vipers (genus Echis) are considered to cause a higher global
snakebite mortality than any other snake. Echis carinatus sochureki (ECS) is a widely …