Steroidal saponins: naturally occurring compounds as inhibitors of the hallmarks of cancer

S Bouabdallah, A Al-Maktoum, A Amin - Cancers, 2023 - mdpi.com
Simple Summary Cancer is one of the most life-threatening diseases that affects a rapidly
growing number of individuals worldwide. Currently, chemotherapy is the most common …

Comprehensive review of Bcl‐2 family proteins in cancer apoptosis: Therapeutic strategies and promising updates of natural bioactive compounds and small …

Iksen, W Witayateeraporn, B Hardianti… - Phytotherapy …, 2024 - Wiley Online Library
Cancer has a considerably higher fatality rate than other diseases globally and is one of the
most lethal and profoundly disruptive ailments. The increasing incidence of cancer among …

Preclinical Characterization of 22-(4′-Pyridinecarbonyl) Jorunnamycin A against Lung Cancer Cell Invasion and Angiogenesis via AKT/mTOR Signaling

I Iksen, S Seephan, V Limprasutr… - ACS Pharmacology & …, 2023 - ACS Publications
Non-small-cell lung cancer (NSCLC), the most prevalent form of lung cancer, is associated
with an unfavorable prognosis owing to its high rate of metastasis. Thus, the identification of …

Deciphering the toxicity-effect relationship and action patterns of traditional Chinese medicines from a smart data perspective: a comprehensive review

Y Li, X Deng, H Xiong, Q Hu, Y Chen… - Frontiers in …, 2023 - frontiersin.org
In Chinese medicine, the primary considerations revolve around toxicity and effect. The
clinical goal is to achieve maximize effect while minimizing toxicity. Nevertheless, both …

Elucidation of the mechanism of action of ailanthone in the treatment of colorectal cancer: integration of network pharmacology, bioinformatics analysis and …

S Ma, X Guo, R Han, Q Meng, Y Zhang… - Frontiers in …, 2024 - frontiersin.org
Background: Ailanthone, a small compound derived from the bark of Ailanthus altissima
(Mill.) Swingle, has several anti-tumour properties. However, the activity and mechanism of …

Light-Mediated Transformation of Renieramycins and Semisynthesis of 4′-Pyridinecarbonyl-Substituted Renieramycin-Type Derivatives as Potential Cytotoxic …

S Sinsook, K Buaban, I Iksen, K Petsri, B Innets… - Marine Drugs, 2023 - mdpi.com
The semisynthesis of renieramycin-type derivatives was achieved under mild and facile
conditions by attaching a 1, 3-dioxole-bridged phenolic moiety onto ring A of the …

Network pharmacology-and cell-based assessments identify the FAK/Src pathway as a molecular target for the antimetastatic effect of momordin Ic against …

P Pocasap, A Prawan, S Kongpetch, L Senggunprai - Heliyon, 2024 - cell.com
Previous studies have indicated the efficacy of momordin Ic (MIc), a plant-derived
triterpenoid, against several types of cancers, implying its potential for further development …

[PDF][PDF] Identification of potential molecular target of hypertension from Allium schoenoprasum by using network pharmacology and molecular docking strategies

AT Pradana, G Haro, N Marbun, S Rahmi… - Pharmacia, 2023 - pharmacia.pensoft.net
Hypertension is one of the silent killers in human life which is characterized by uncontrolled
blood pressure. Although many therapeutic drugs have demonstrated success in treating …

[PDF][PDF] THE POTENTIAL EFFECT OF APORPHINE ALKALOIDS FROM NELUMBO NUCIFERA GAERTN. AS ANTI-BREAST CANCER BASED ON NETWORK …

MFL ADRIAN, RA SYAHPUTRA, R ASTYKA… - Int J App …, 2024 - academia.edu
Objective: To demonstrate the efficacy and benefits of aporphine alkaloids from Nelumbo
nucifera Gaertn. as anti-breast cancer agents. Methods: In this study, a combination of …

Exploring The Potential Targets and Mechanisms of Vitexdoins Family Against Polycystic Ovary Syndrome Based on Network Pharmacology

H Simanjuntak, N Marbun, HD Syahputra… - Egyptian Journal of …, 2023 - journals.ekb.eg
The effects of polycystic ovarian syndrome (PCOS) on women's health and happiness are
substantial. Traditional medicines and natural products have gained popularity as potential …