Ferulic, sinapic, 3, 4-dimethoxycinnamic acid and indomethacin derivatives with antioxidant, anti-inflammatory and hypolipidemic functionality

P Theodosis-Nobelos, G Papagiouvannis, EA Rekka - Antioxidants, 2023 - mdpi.com
A series of thiomorpholine and cinnamyl alcohol derivatives, conjugated with cinnamic acid-
containing moieties, such as ferulic acid, sinapic acid and 3, 4-dimethoxycinnamic acid …

Design, synthesis and evaluation of ursodeoxycholic acid-cinnamic acid hybrids as potential anti-inflammatory agents by inhibiting Akt/NF-κB and MAPK signaling …

X Li, Y Hu, B He, L Li, Y Tian, Y Xiao, H Shang… - European Journal of …, 2023 - Elsevier
A series of ursodeoxycholic acid (UDCA)-cinnamic acid hybrids were designed and
synthesized. The anti-inflammatory activity of these derivatives was screened through …

Induction of mitochondrial toxicity by non-steroidal anti-inflammatory drugs (NSAIDs): The ultimate trade-off governing the therapeutic merits and demerits of these …

S Mazumder, S Bindu, S Debsharma… - Biochemical …, 2024 - Elsevier
Non-steroidal anti-inflammatory drugs (NSAIDs) are most extensively used over-the-counter
FDA-approved analgesic medicines for treating inflammation, musculoskeletal pain, arthritis …

[HTML][HTML] Plant-derived and dietary phenolic cinnamic acid derivatives: Anti-inflammatory properties

M Freitas, D Ribeiro, JS Janela, CL Varela, SC Costa… - Food Chemistry, 2024 - Elsevier
Cinnamic acids are aromatic acids primarily found in plants and plant-derived food. Phenolic
cinnamic acids, with one or more hydroxyl groups in the aromatic ring, often contribute to the …

Antioxidant and Hypolipidemic Activities of Cinnamic Acid Derivatives

C Nouni, P Theodosis-Nobelos, EA Rekka - Molecules, 2023 - mdpi.com
Oxidative stress and hyperlipidemia are important factors for the initiation and progression of
various cell degenerative pathological conditions, including cardiovascular and neurological …

Design, synthesis and evaluation of antioxidant and NSAID derivatives with antioxidant, anti-inflammatory and plasma lipid lowering effects

P Theodosis-Nobelos, G Marc, EA Rekka - Molecules, 2024 - mdpi.com
Amides containing methyl esters of γ-aminobutyric acid (GABA), L-proline and L-tyrosine,
and esters containing 3-(pyridin-3-yl) propan-1-ol were synthesized by conjugation with 3, 5 …

An Innovative Approach to a Potential Neuroprotective Sideritis scardica-Clinoptilolite Phyto-Nanocarrier: In Vitro Investigation and Evaluation

AE Segneanu, G Vlase, T Vlase, A Bita… - International Journal of …, 2024 - mdpi.com
The cutting-edge field of nanomedicine combines the power of medicinal plants with
nanotechnology to create advanced scaffolds that boast improved bioavailability …

[HTML][HTML] Trolox, Ferulic, Sinapic, and Cinnamic Acid Derivatives of Proline and GABA with Antioxidant and/or Anti-Inflammatory Properties

G Papagiouvannis, P Theodosis-Nobelos, EA Rekka - Molecules, 2024 - mdpi.com
Degenerative conditions, such as neurodegenerative disorders (Alzheimer's disease (AD),
Parkinson's disease (PD)) and cardiovascular diseases, are complex, multifactorial …

Nipecotic Acid Derivatives as Potent Agents against Neurodegeneration: A Preliminary Study

G Papagiouvannis, P Theodosis-Nobelos, EA Rekka - Molecules, 2022 - mdpi.com
Alzheimer's Disease (AD) is a common neurodegenerative disorder characterized by
memory loss and cognitive impairment. Its pathology has not been fully clarified and …

Romanian Wild-Growing Chelidonium majus—An Emerging Approach to a Potential Antimicrobial Engineering Carrier System Based on AuNPs: In Vitro Investigation …

AE Segneanu, G Vlase, T Vlase, MV Ciocalteu… - Plants, 2024 - mdpi.com
Novel nanotechnology based on herbal products aspires to be a high-performing
therapeutic platform. This study reports the development of an original engineering carrier …