The total and regional peripheral resistance and capacitance of the vascular system is
regulated by the sympathetic nervous system, which influences the vasculature mainly …

Different studies have led to our present knowledge of the membrane receptors responsible
for mediating the responses to the endogenous catecholamines. These receptors were …

The a, ARs are important mediators of sympathetic nervous system responses, particularly
those involved in cardiovascular homeostasis, such as arteriolar smooth muscle constriction …

α1-Adrenoceptors are one of three subfamilies of receptors (α1, α2, β) mediating responses
to adrenaline and noradrenaline. Three α1-adrenoceptor subtypes are known (α1A, α1B …

Several of the established α1-, α2-and β-adrenoceptors have now been isolated and cloned.
The in situ hybridization method has been used to map the distribution of many of these …

Objective: This meta-analysis of two European studies evaluated the efficacy and safety of
modified-release tamsulosin 0.4 mg once daily compared with placebo in patients with …

We compared 5-hydroxytryptamine (5-HT), norepinephrine and dopamine for their efficacy
at increasing excitatory postsynaptic current frequency in layer V pyramidal cells from rat …

BMY 7378 (8-[2-[4-(2-methoxyphenyl)-1-piperazinyl] ethyl]-8-azaspiro [4.5] decane-7, 9-
dione dihydrochloride), a 5-HT1A receptor partial agonist, also binds to α1-adrenoceptors …

Objective To evaluate the efficacy and safety of tamsulosin 0.4 mg once daily (as a modified‐
release formulation) compared with placebo in patients with benign prostatic enlargement …

Blockade of the actions of the sympathetic neu-rotransmitter norepinephrine and the
neurohormone epinephrine at a-and/3-adrenoceptors has represented an important …