Protein–protein interactions (PPIs) are implicated in the majority of cellular processes by
enabling and regulating the function of individual proteins. Thus, PPIs represent high-value …

Technological advances and breakthrough developments in the pharmaceutical field are
knocking at the door of the “undruggable” fortress with increasing insistence. Notably, the …

The use of antibiotics is threatened by the emergence and spread of multidrug-resistant
strains of bacteria. Thus, there is a need to develop antibiotics that address new targets. In …

Recurrent chromosomal rearrangements found in rhabdomyosarcoma (RMS) produce the
PAX3–FOXO1 fusion protein, which is an oncogenic driver and a dependency in this …

Two decades after their discovery, stapled peptide methodologies have evolved to a point
where they can be used with confidence to generate therapeutic leads. Research groups …

The pharmacodynamic and pharmacokinetic properties of bioactive peptides can be
modulated by introducing conformational constraints such as intramolecular …

Following a rational design, a series of macrocyclic (“stapled”) peptidomimetics of 10Panx1,
the most established peptide inhibitor of Pannexin1 (Panx1) channels, were developed and …

Two splicing variants exist in NFYA that exhibit high expression in many human tumour
types. The balance in their expression correlates with prognosis in breast cancer, but …

Direct transfer of protons and electrons between two tandem reactions is still a great
challenge, because overall reaction kinetics is seriously affected by diffusion rate of the …

The rising incidence of multidrug resistance in Gram-negative bacteria underlines the
urgency for novel treatment options. One promising new approach is the synergistic …